ADCY7, adenylate cyclase 7, 113

N. diseases: 38; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group BEFREE This converging cross-species evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression, together supporting a continuous dimensional approach to major depressive disorder and other affective disorders. 22264442 2012
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group PSYGENET This converging cross-species evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression, together supporting a continuous dimensional approach to major depressive disorder and other affective disorders. 22264442 2012
CUI: C4552091
Disease: Polyarthritis, Juvenile, Rheumatoid Factor Negative
Polyarthritis, Juvenile, Rheumatoid Factor Negative 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C4704862
Disease: Polyarthritis, Juvenile, Rheumatoid Factor Positive
Polyarthritis, Juvenile, Rheumatoid Factor Positive 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.300 Biomarker disease CTD_human Exome sequencing supports a de novo mutational paradigm for schizophrenia. 21822266 2011
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Both PECAM1 and ADCY7 promoted tumor progression through the AKT pathway, showing the same molecular mechanism as CD300A. 29938007 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Adenylate cyclase 7 (AC7) has been reported to participate in various biological processes during cancer progression. 30366671 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 GeneticVariation disease GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 Biomarker disease CTD_human We discovered a 0.6% frequency missense variant in ADCY7 that doubles the risk of ulcerative colitis. 28067910 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 GeneticVariation disease GWASCAT We discovered a 0.6% frequency missense variant in ADCY7 that doubles the risk of ulcerative colitis. 28067910 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 GeneticVariation disease BEFREE We discovered a 0.6% frequency missense variant in ADCY7 that doubles the risk of ulcerative colitis. 28067910 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 Biomarker disease PSYGENET We also completed studies with humans on the association of polymorphisms in the AC7 gene with major depressive illness (unipolar depression) based on Diagnostic and Statistical Manual of Mental Disorders IV criteria. 17135423 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 Biomarker disease PSYGENET This converging cross-species evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression, together supporting a continuous dimensional approach to major depressive disorder and other affective disorders. 22264442 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 GeneticVariation disease BEFREE We also completed studies with humans on the association of polymorphisms in the AC7 gene with major depressive illness (unipolar depression) based on Diagnostic and Statistical Manual of Mental Disorders IV criteria. 17135423 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 Biomarker disease BEFREE This converging cross-species evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression, together supporting a continuous dimensional approach to major depressive disorder and other affective disorders. 22264442 2012