CHRM3, cholinergic receptor muscarinic 3, 1131

N. diseases: 284; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033770
Disease: Prune Belly Syndrome
Prune Belly Syndrome 		0.650 Biomarker disease BEFREE T2DM mouse model was induced by high-fat-diet, and the mice were treated with fenofibrate (100 mg/kg) (DIO-FENO) or PBS (DIO-PBS) for 4 weeks. 29029615 2017
CUI: C0033770
Disease: Prune Belly Syndrome
Prune Belly Syndrome 		0.650 Biomarker disease BEFREE Animals received four weekly injections of either PBS (G1), ConvitVax (200 μg cell homogenate, 0.0625 mg BCG, 0.02% formalin) (G2), 50 μg anti-PD-1 (G3), or ConvitVax plus anti-PD-1 (200 μg cell homogenate, 0.0625 mg BCG, 0.02% formalin, 50 μg anti-PD-1) (G4). 31762937 2019
CUI: C0033770
Disease: Prune Belly Syndrome
Prune Belly Syndrome 		0.650 Biomarker disease BEFREE Here, we employed BALB/c ByJ mice inflected with SP, IAV, IAV followed by SP (IAV+SP) and PBS (Control) as models to survey the global gene expression using digital gene expression (DGE) profiling. 29348862 2017
CUI: C0033770
Disease: Prune Belly Syndrome
Prune Belly Syndrome 		0.650 GeneticVariation disease BEFREE Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome. 22077972 2011
CUI: C0033770
Disease: Prune Belly Syndrome
Prune Belly Syndrome 		0.650 GeneticVariation disease BEFREE Finally, in a murine model of type 1 diabetes, NTA-modified complex micelles loading an insulin (NTA-CM-INS) group exhibited a long hypoglycemic effect which is superior to that of free insulin in the PBS (PBS-INS) group and insulin-loaded complex micelles without an NTA modification (CM-INS) group. 30212220 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.410 AlteredExpression disease BEFREE We used this assay to measure CHRM3 protein levels in the frontal pole, obtained post-mortem from subjects with bipolar disorder (n = 15), major depressive disorder (n = 15) and matched controls (n = 20) and showed that [(3)H]4-DAMP binding was not altered in either bipolar disorder or major depressive disorder. 23962466 2013
CUI: C0005686
Disease: Urinary Bladder Diseases
Urinary Bladder Diseases 		0.320 GeneticVariation group BEFREE This is the first independent report of biallelic variants in CHRM3 in a family with a rare serious bladder disorder associated with mydriasis and provides important evidence of this association. 31441039 2019
CUI: C0005686
Disease: Urinary Bladder Diseases
Urinary Bladder Diseases 		0.320 GeneticVariation group BEFREE Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome. 22077972 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 AlteredExpression disease BEFREE We used this assay to measure CHRM3 protein levels in the frontal pole, obtained post-mortem from subjects with bipolar disorder (n = 15), major depressive disorder (n = 15) and matched controls (n = 20) and showed that [(3)H]4-DAMP binding was not altered in either bipolar disorder or major depressive disorder. 23962466 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 AlteredExpression disease BEFREE We used this assay to measure CHRM3 protein levels in the frontal pole, obtained post-mortem from subjects with bipolar disorder (n = 15), major depressive disorder (n = 15) and matched controls (n = 20) and showed that [(3)H]4-DAMP binding was not altered in either bipolar disorder or major depressive disorder. 23962466 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 AlteredExpression group BEFREE The use of a modified [3H]4-DAMP radioligand binding assay with increased selectivity for muscarinic M3 receptor shows that cortical CHRM3 levels are not altered in mood disorders. 23962466 2013
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.140 Biomarker disease BEFREE After successful construction of COPD mouse model by CS, HE staining illustrated that the structure of airway wall of lung tissue in mice from PBS group was irregular. 29630123 2018
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.140 Biomarker disease BEFREE We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications. 28166213 2017
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.140 AlteredExpression disease BEFREE Also, CHRM3 gene expression was significantly elevated in COPD patients with BHR as compared with patients without BHR. 22192964 2012
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.140 GeneticVariation disease BEFREE Eighty-two patients with COPD and 17 healthy smokers were recruited and screened for ADRb2 (T164I and R175R), for CHRM2 (rs1824024) and for CHRM3 (-513C/A and -492C/T). 26633752 2016
CUI: C0009806
Disease: Constipation
Constipation 		0.130 GeneticVariation phenotype BEFREE Generalized linear univariate model analysis performed on the opiate-induced constipation-associated SNPs and a single CHRM3 SNP revealed an association between anticholinergic symptoms and a score of 8 SNPs (adjusted P = 0.038, permuted P = 0.002). 29620694 2018
CUI: C0009806
Disease: Constipation
Constipation 		0.130 Biomarker phenotype BEFREE Excess risk of IC/PBS was observed in the first- and second-degree relatives in probands with myalgia and myositis/unspecified (fibromyalgia) and in probands with constipation. 25349937 2016
CUI: C0009806
Disease: Constipation
Constipation 		0.130 Biomarker phenotype BEFREE The control and constipation group received 1× PBS under the same pattern. 30122898 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.110 Biomarker disease BEFREE Moreover, two candidate genes for therapeutic targeting came out from this analysis: SSTR1, a relevant common hub in febrile and afebrile transcriptomes, and CHRM3, due to its putative role in epilepsy susceptibility development. 22022585 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 Biomarker disease BEFREE Male C57BL/6 mice were subjected to left coronary artery ligation to induce MI and then treated with MCC950 (10 mg/kg) or PBS for 14 days. 31299609 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 Biomarker disease BEFREE Wistar rats were subjected to left anterior descending artery ligation to induce myocardial infarction (MI) and then randomly allocated to receive an intramyocardial injection of PBS (MI group) or 5-azacytidine-induced MSCs (MSCs group). 28929261 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 Biomarker disease BEFREE NOD/SCID mice were treated with hiPSC-CCND2<sup>OE</sup> CMs (i.e., the CCND2<sup>OE</sup> group), hiPSC-CCND2<sup>WT</sup> CMs (the CCND2<sup>WT</sup> group), or an equal volume of PBS immediately after experimentally-induced myocardial infarction. 31629738 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 Biomarker disease BEFREE Phosphate-buffered solution (PBS group), Dex-PCL-HEMA/PNIPAAm hydrogel (Gel group), bFGF in phosphate-buffered solution (bFGF group) or bFGF in hydrogel (Gel + bFGF group) was injected into a peri-infarcted area of cardiac tissue immediately following MI. 29042955 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 Biomarker disease BEFREE Magnetic resonance imaging (MRI) revealed that the microvascular grafts effectively preserved contractile performance 3 d and 6 wk after myocardial infarction, attenuated left ventricular dilation, and decreased infarct size as compared to infarcted rats treated with PBS injection as a control (3 d ejection fraction, + ∼7%, P < 0.001; 6 wk ejection faction, + ∼12%, P < 0.001). 21035182 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 Biomarker disease BEFREE Male Balb/C mice were subjected to MI or sham operation; the infarcted animals were subdivided to receive intramyocardial injections of PBS, GILZ overexpressing cells (GILZ) or their controls expressing the green fluorescent protein (GFP). 28499885 2017