Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.310 Biomarker disease BEFREE Survival analysis of all HCC patients in TCGA indicated that the overall survival and disease-free survival were not significantly associated with <i>VSIG4</i> expression. 30288101 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.310 Biomarker disease CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560 2017
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.300 Biomarker disease CTD_human The molecular phenotype of endocapillary proliferation: novel therapeutic targets for IgA nephropathy. 25133636 2014
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.300 Biomarker disease CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229 2008
CUI: C0026998
Disease: Acute Myeloid Leukemia, M1
Acute Myeloid Leukemia, M1
0.300 Biomarker disease CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229 2008
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2)
0.300 Biomarker disease CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229 2008
CUI: C0002170
Disease: Alopecia
Alopecia
0.100 GeneticVariation disease GWASCAT Genetic prediction of male pattern baldness. 28196072 2017
CUI: C0003864
Disease: Arthritis
Arthritis
0.020 Biomarker disease BEFREE Here, we further addressed the specificity and assessed the potential for arthritis monitoring using near-infrared fluorescence (NIRF) Cy7-labeled Vsig4 nanobody (Cy7-Nb119). 31288389 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.020 Biomarker disease BEFREE The Ig superfamily protein PTGFRN coordinates survival signaling in glioblastoma multiforme. 31377205 2019
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.020 Biomarker disease BEFREE The Ig superfamily protein PTGFRN coordinates survival signaling in glioblastoma multiforme. 31377205 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.020 Biomarker disease BEFREE Contrary to VSIG4, we demonstrated that overexpressing let-7g-5p promoted mesenchymal-epithelial transition (MET) and significantly inhibited invasion and migration consistent with the reduction of glioblastoma stem cell phenotypes in U-87MG cells. 27634309 2016
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.020 Biomarker disease BEFREE Contrary to VSIG4, we demonstrated that overexpressing let-7g-5p promoted mesenchymal-epithelial transition (MET) and significantly inhibited invasion and migration consistent with the reduction of glioblastoma stem cell phenotypes in U-87MG cells. 27634309 2016
CUI: C0003864
Disease: Arthritis
Arthritis
0.020 Biomarker disease BEFREE A soluble form of CRIg reversed inflammation and bone loss in two experimental models of arthritis by inhibiting the AP of complement in the joint. 17548523 2007
CUI: C0432283
Disease: Osteoglophonic dwarfism
Osteoglophonic dwarfism
0.010 AlteredExpression disease BEFREE In vitro, the neuron-glial mixed culture by fluorescent staining showed that oxygen glucose deprivation (OGD) treatment led to significant cell death, while being attenuated by Vsig4 over-expression in primary microglial cells. 31784084 2020
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion
0.010 AlteredExpression disease BEFREE In addition, neurological dysfunction due to MCAO surgery was improved by Vsig4 over-expression. 31784084 2020
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.010 AlteredExpression disease BEFREE Finally, we showed that Vsig4 could interact with TLR4 and repress its expression, subsequently alleviating ischemic stroke. 31784084 2020
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm
0.010 Biomarker disease BEFREE Among all DEGs, 5 down-regulated genes (MYH11, CNN1, MYOCD, ACTA1, and LMOD1) and 3 up-regulated genes (C1QB, C3AR1, and VSIG4) are most relevant in IA formation. 31238169 2019
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.010 Biomarker disease BEFREE The agonistic VSIG4 antibodies (VG11), acting through NLRP3 and IL-1β suppression, show significant therapeutic efficacy in mouse EAE. 30662948 2019
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.010 Biomarker disease BEFREE Survival analysis showed that except VSIG4, other hub genes may be involved in the development of LUAD, in which MYH10, METTL7A, FCER1G and TMOD1 have not been reported previously to correlated with LUAD. 31333911 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.010 AlteredExpression disease BEFREE Older patients with prostate cancer (>60 years old) in The Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) dataset displayed higher expression of macrophage markers (CD163 and VSIG4) which associated with higher rates of biochemical relapse. 30224545 2019
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.010 AlteredExpression disease BEFREE Here, we attempted to explore if Vsig4 expression was involved in high fat diet (HFD)-induced NAFLD. 31266632 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.010 AlteredExpression disease BEFREE Older patients with prostate cancer (>60 years old) in The Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) dataset displayed higher expression of macrophage markers (CD163 and VSIG4) which associated with higher rates of biochemical relapse. 30224545 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.010 Biomarker disease BEFREE Finally, transplantation of bone marrow cells from control mice to Vsig4-knockout mice restored the severity of steatosis, inflammation and fibrosis after HFD feeding. 31266632 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.010 Biomarker group BEFREE Here, we review our current understanding of the diverse roles of CRIg in pathogen elimination, anti-microbial immunity and autoimmunity. 29573978 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.010 Biomarker disease BEFREE Correlation analysis between unexplored hub genes and clinical features of DN suggested that COL6A3, MS4A6A,PLCE1, TNNC1, TNNI1, TNN2, and VSIG4 may involve in the progression of DN. 30485525 2018