Liver carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
Survival analysis of all HCC patients in TCGA indicated that the overall survival and disease-free survival were not significantly associated with <i>VSIG4</i> expression.
|
30288101 |
2018 |
Liver carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
IGA Glomerulonephritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
The molecular phenotype of endocapillary proliferation: novel therapeutic targets for IgA nephropathy.
|
25133636 |
2014 |
Leukemia, Myelocytic, Acute
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
Acute Myeloid Leukemia, M1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
Acute Myeloid Leukemia (AML-M2)
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
Alopecia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic prediction of male pattern baldness.
|
28196072 |
2017 |
Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we further addressed the specificity and assessed the potential for arthritis monitoring using near-infrared fluorescence (NIRF) Cy7-labeled Vsig4 nanobody (Cy7-Nb119).
|
31288389 |
2019 |
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The Ig superfamily protein PTGFRN coordinates survival signaling in glioblastoma multiforme.
|
31377205 |
2019 |
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
The Ig superfamily protein PTGFRN coordinates survival signaling in glioblastoma multiforme.
|
31377205 |
2019 |
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Contrary to VSIG4, we demonstrated that overexpressing let-7g-5p promoted mesenchymal-epithelial transition (MET) and significantly inhibited invasion and migration consistent with the reduction of glioblastoma stem cell phenotypes in U-87MG cells.
|
27634309 |
2016 |
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Contrary to VSIG4, we demonstrated that overexpressing let-7g-5p promoted mesenchymal-epithelial transition (MET) and significantly inhibited invasion and migration consistent with the reduction of glioblastoma stem cell phenotypes in U-87MG cells.
|
27634309 |
2016 |
Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
A soluble form of CRIg reversed inflammation and bone loss in two experimental models of arthritis by inhibiting the AP of complement in the joint.
|
17548523 |
2007 |
Osteoglophonic dwarfism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In vitro, the neuron-glial mixed culture by fluorescent staining showed that oxygen glucose deprivation (OGD) treatment led to significant cell death, while being attenuated by Vsig4 over-expression in primary microglial cells.
|
31784084 |
2020 |
Middle Cerebral Artery Occlusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, neurological dysfunction due to MCAO surgery was improved by Vsig4 over-expression.
|
31784084 |
2020 |
Ischemic stroke
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, we showed that Vsig4 could interact with TLR4 and repress its expression, subsequently alleviating ischemic stroke.
|
31784084 |
2020 |
Intracranial Aneurysm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among all DEGs, 5 down-regulated genes (MYH11, CNN1, MYOCD, ACTA1, and LMOD1) and 3 up-regulated genes (C1QB, C3AR1, and VSIG4) are most relevant in IA formation.
|
31238169 |
2019 |
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The agonistic VSIG4 antibodies (VG11), acting through NLRP3 and IL-1β suppression, show significant therapeutic efficacy in mouse EAE.
|
30662948 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Survival analysis showed that except VSIG4, other hub genes may be involved in the development of LUAD, in which MYH10, METTL7A, FCER1G and TMOD1 have not been reported previously to correlated with LUAD.
|
31333911 |
2019 |
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Older patients with prostate cancer (>60 years old) in The Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) dataset displayed higher expression of macrophage markers (CD163 and VSIG4) which associated with higher rates of biochemical relapse.
|
30224545 |
2019 |
Non-alcoholic Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we attempted to explore if Vsig4 expression was involved in high fat diet (HFD)-induced NAFLD.
|
31266632 |
2019 |
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Older patients with prostate cancer (>60 years old) in The Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) dataset displayed higher expression of macrophage markers (CD163 and VSIG4) which associated with higher rates of biochemical relapse.
|
30224545 |
2019 |
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, transplantation of bone marrow cells from control mice to Vsig4-knockout mice restored the severity of steatosis, inflammation and fibrosis after HFD feeding.
|
31266632 |
2019 |
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we review our current understanding of the diverse roles of CRIg in pathogen elimination, anti-microbial immunity and autoimmunity.
|
29573978 |
2018 |
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Correlation analysis between unexplored hub genes and clinical features of DN suggested that COL6A3, MS4A6A,PLCE1, TNNC1, TNNI1, TNN2, and VSIG4 may involve in the progression of DN.
|
30485525 |
2018 |