Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analysis further established that the expression of monoglyceride lipase was restricted to ductal breast cancer and present in 77% of these tumors, while Vav1 was restricted to MCB and present in 60% of tumors.
|
16685433 |
2006 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Impairments in MAGL-dependent tumor growth are rescued by a high-fat diet, indicating that exogenous sources of fatty acids can contribute to malignancy in cancers lacking MAGL activity.
|
20079333 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MAGL expression in tumor tissues was estimated, and then JZL184 and siRNA were used to knockdown the expression of MAGL in colorectal cancer cells.
|
21543155 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, overexpression of MGL suppressed colony formation in tumor cell lines and knockdown of MGL resulted in increased Akt phosphorylation.
|
22349814 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Specifically, high MAGL expression was found in tumors with larger tumor size, microvascular invasion, poor differentiation, or advanced TNM stage.
|
27884159 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study unravels a novel mechanism of SND1 function and identifies MGLL as a unique tumor suppressor for HCC.
|
26997225 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In experiments aiming at investigating the role of MAGL in chemoprevention, URB602 attenuated azoxymethane-induced preneoplastic lesions, polyps and tumors.
|
28193521 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Since the STn glycan decoration is more frequently found on the surface of carcinomas than the Tn glycan, the binding of MUC1 carrying STn to MGL may be more physiologically relevant and may be in part responsible for some of the characteristics of STn expressing tumours.
|
28414807 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To correlate the tumour expression status of MAGL with the clinicopathological information of patients with malignant melanoma.
|
28681540 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that MGL-deficient (MGL<sup>+/-</sup>, MGL<sup>-/-</sup>) mice exhibited a higher incidence of neoplasia in multiple organs, including the lung, spleen, liver and lymphoid tissues.
|
29348400 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, we present prognostic value for MGL ligand expression in SCC/ASC patients, which further supports an immune evasive role for the C-type lectin MGL in the tumor immune compartment.
|
30761272 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer.
|
31357249 |
2019 |