|
Focal glomerulosclerosis
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Myo-inositol treatment ameliorated the decreased expression of ZO-1 and synaptopodin in an in vitro FSGS model, and as myo-inositol increased, myo-inositol oxygenase tissue expression decreased proportionally to eGFR.
|
31605028 |
2019 |
|
Focal glomerulosclerosis
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
For the FSGS group, the rate of renal function decline significantly correlated with baseline urinary synaptopodin mRNA levels (r = -0.496, p = 0.012).
|
26308082 |
2015 |
|
Focal glomerulosclerosis
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Compared with normal glomeruli, fewer cells stained for APOL1 in FSGS and HIVAN glomeruli, even when expression of the podocyte markers GLEPP1 and synaptopodin appeared normal.
|
21997392 |
2011 |
|
Focal glomerulosclerosis
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
So we presumed that the ACTN4 and SYNPO promoter mutations might also contribute to pathophysiology of idiopathic FSGS.
|
19666657 |
2010 |
|
Focal glomerulosclerosis
|
0.370 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
So we presumed that the ACTN4 and SYNPO promoter mutations might also contribute to pathophysiology of idiopathic FSGS.
|
19666657 |
2010 |
|
Focal glomerulosclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Moreover, bigenic heterozygosity for synaptopodin and CD2AP is sufficient to induce spontaneous proteinuria and focal segmental glomerulosclerosis-like glomerular damage in mice.
|
17569780 |
2007 |
|
Focal glomerulosclerosis
|
0.370 |
AlteredExpression
|
disease |
LHGDN |
We investigated the association between expression of synaptopodin and glomerular epithelial protein 1 (GLEPP1) and response to corticosteroid therapy in primary FSGS.
|
16564554 |
2006 |
|
Focal glomerulosclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Combinations of Cd2ap heterozygosity and heterozygosity of either synaptopodin (Synpo) or Fyn proto-oncogene (Fyn) but not kin of IRRE like 1 (Neph1) resulted in spontaneous proteinuria and in FSGS-like glomerular damage.
|
16628251 |
2006 |
|
Focal Segmental Glomerulosclerosis, Not Otherwise Specified
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Functional analysis of promoter mutations in the ACTN4 and SYNPO genes in focal segmental glomerulosclerosis.
|
19666657 |
2010 |
|
Focal Segmental Glomerulosclerosis, Not Otherwise Specified
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
So we presumed that the ACTN4 and SYNPO promoter mutations might also contribute to pathophysiology of idiopathic FSGS.
|
19666657 |
2010 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Nephroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Simultaneously, HG decreased the mRNA and protein expression of Wilm's tumor-1 and synaptopodin, and increased the mRNA and protein expression levels of desmin in podocytes, in a dose-dependent manner.
|
30257355 |
2018 |
|
Nephroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The expression of Wilms tumor 1 (WT-1) and synaptopodin was evaluated to identify differentiated podocytes, and the expression of nephrin, podocin, and CD2ap was measured as markers of slit diaphragms, the main structures within the glomerular filtration barrier.
|
28719912 |
2017 |
|
Nephroblastoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Using an immunohistochemical technique, we examined the natural course of nephrin, Wilms' tumor-1 (WT1) and synaptopodin at 16.5 days of embryonic age (E16.5d) and E19.5d, 7 days of post-neonatal age (P7d) and P42d during renal development of mice.
|
28179596 |
2017 |
|
Nephroblastoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
WT1(R458Q) overexpression significantly downregulated nephrin and synaptopodin expression, promoted apoptosis in HEK293 cells and impaired focal contact formation in podocytes.
|
25145932 |
2015 |
|
Kidney Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
In this review, we will focus on slit diaphragm proteins such as nephrin, podocin, TRPC6/5, as well as cytoskeletal proteins Rho/small GTPases and synaptopodin and their respective roles in participating in the pathogenesis of proteinuric kidney diseases.
|
30255020 |
2018 |
|
Kidney Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
Because nephrin and synaptopodin are essential for the maintenance of the slit diaphragm in podocytes, these results suggest that proteinuria in adriamycin-induced nephropathy is caused by the reduction in expression of these proteins.
|
27089875 |
2017 |
|
Kidney Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
We identified a progressive loss of synaptopodin expression over a 28 day time-course of ADR nephropathy which was associated with increased acetylation of 14-3-3β and reduced synaptopodin phosphorylation.
|
23840712 |
2013 |
|
Renal glomerular disease
|
0.020 |
Biomarker
|
group |
BEFREE |
This review aims to summarize recent findings on the role of MAGI-2 and some other scaffold proteins, such as nephrin and synaptopodin, in the underlying mechanisms of glomerulopathy.
|
30110567 |
2018 |
|
Membranous glomerulonephritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Histone H3K4 me3 in kidney podocytes was negatively correlated with synaptopodin, an actin-associated protein in podocytes, and the expression was positively correlated with the proteinuria levels in patients with MN.
|
27855638 |
2016 |
|
Schizophrenia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
From the PGC results, other SYNPO variants were identified with near significant effects on schizophrenia risk, with a local linkage disequilibrium block displaying signatures of positive selection.
|
26405221 |
2016 |
|
Membranous glomerulonephritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This overexpression was associated with the downregulation of synaptopodin in patients with membranous nephropathy, rats with passive Heymann nephritis, and c-mip transgenic mice, while the abundance of death-associated protein kinase and integrin-linked kinase was increased.
|
23302718 |
2013 |
|
Schizophrenia
|
0.020 |
Biomarker
|
disease |
BEFREE |
We measured transcript levels of CDC42, CDC42EP3, CDC42EP4; their interacting proteins (septins [SEPT2, 3, 5, 6, 7, 8, and 11], anillin), and other spine-specific proteins (spinophilin, PSD-95, and synaptopodin) in the DLPFC from 31 subjects with schizophrenia and matched normal comparison subjects.
|
20385374 |
2010 |
|
Primary Focal Segmental Glomerulosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To investigate the promoter mutations of ACTN4 and SYNPO genes in patients with idiopathic focal segmental glomerulosclerosis (FSGS), and to provide functional analysis of these mutations in the role of FSGS occurrence.
|
19666657 |
2010 |
|
Primary Focal Segmental Glomerulosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of both synaptopodin and GLEPP1 is associated with poor response to steroid therapy in primary FSGS.
|
16564554 |
2006 |