SYNPO, synaptopodin, 11346

N. diseases: 37; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.040 AlteredExpression disease BEFREE Simultaneously, HG decreased the mRNA and protein expression of Wilm's tumor-1 and synaptopodin, and increased the mRNA and protein expression levels of desmin in podocytes, in a dose-dependent manner. 30257355 2018
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.040 AlteredExpression disease BEFREE The expression of Wilms tumor 1 (WT-1) and synaptopodin was evaluated to identify differentiated podocytes, and the expression of nephrin, podocin, and CD2ap was measured as markers of slit diaphragms, the main structures within the glomerular filtration barrier. 28719912 2017
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.040 GeneticVariation disease BEFREE Using an immunohistochemical technique, we examined the natural course of nephrin, Wilms' tumor-1 (WT1) and synaptopodin at 16.5 days of embryonic age (E16.5d) and E19.5d, 7 days of post-neonatal age (P7d) and P42d during renal development of mice. 28179596 2017
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.040 GeneticVariation disease BEFREE WT1(R458Q) overexpression significantly downregulated nephrin and synaptopodin expression, promoted apoptosis in HEK293 cells and impaired focal contact formation in podocytes. 25145932 2015