Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior.
|
31288250 |
2019 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Several genome-wide association and candidate gene studies have linked chromosome 15q24-q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease.
|
22438940 |
2012 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Several genome-wide association and candidate gene studies have linked chromosome 15q24-q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease.
|
22438940 |
2012 |
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Recent human genetic association studies have implicated the gene cluster CHRNA3-CHRNA5-CHRNB4 encoding the α3, α5, and β4 subunits of the nAChR in susceptibility to develop nicotine and alcohol dependence; however, their role in ethanol-mediated behaviors is unknown due to the lack of suitable and selective research tools.
|
21048701 |
2011 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Recent human genetic association studies have implicated the gene cluster CHRNA3-CHRNA5-CHRNB4 encoding the α3, α5, and β4 subunits of the nAChR in susceptibility to develop nicotine and alcohol dependence; however, their role in ethanol-mediated behaviors is unknown due to the lack of suitable and selective research tools.
|
21048701 |
2011 |
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
We also observed two SNPs associated with alcohol dependence, that is, rs615470 in CHRNA5 (OR=0.77, P=0.0006) and rs578776 (OR=0.78, P=0.001).
|
20485328 |
2010 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
We also observed two SNPs associated with alcohol dependence, that is, rs615470 in CHRNA5 (OR=0.77, P=0.0006) and rs578776 (OR=0.78, P=0.001).
|
20485328 |
2010 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
CTD_human |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |
Alcoholic Intoxication, Chronic
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |