Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
CHRNA5/CHRNA3/CHRNB4 gene cluster is located on chromosome 15q25.1 and was reported to be associated with risk of lung cancer.
|
29416783 |
2018 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among them, TP63 (3q28), RP11-650L12.2 (15q25.1) and CHRNA5 (15q25.1) were located in known lung cancer susceptibility loci.
|
29193083 |
2018 |
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
The transcription profile of CHRNA5 depleted MCF7 cells showed a significant positive correlation with that of A549 lung cancer cell line while exhibiting a negative association with the CHRNA5 co-expression profile obtained from Cancer Cell Line Encylopedia (CCLE).
|
30543688 |
2018 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Surprisingly, the most convincing association (a nicotinic acetylcholine receptor <i>CHRNA5-A3-B4</i> gene cluster in nicotine dependence), with a unique attributable risk of 14%, was detected through a genome-wide association study (GWAS) on lung cancer, although lung cancer has a low heritability.
|
29302221 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
|
28604730 |
2017 |
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies (GWAS) show that CHRNA5 gene encoding α5-nAChR is especially relevant to lung cancer.
|
28750889 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, these SNPs are rare in Asians, and there is currently no consensus on whether SNPs in CHRNA5-A3-B4 have a direct or indirect carcinogenic effect through smoking behaviors on lung cancer risk.
|
26942719 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.
|
26689306 |
2016 |
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) in the cholinergic nicotinic receptor subunit genes on chromosome 15q25.1, including CHRNA3, CHRNB4 and CHRNA5, are well-established biomarkers of chronic obstructive pulmonary disease (COPD) and lung cancer.
|
27462996 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent.
|
27072204 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CPD was found to be a nominally significant effect modifier between SNP and lung cancer for six SNPs, including CHRNA5 rs2036527[A](betaSNP*CPD = - 0.017, p = 0.0061, corrected p = 0.054), which was associated with CPD in a previous genome-wide meta-analysis of African-Americans.
|
26981579 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Smokers with high-risk CHRNA5 genotypes, on average, can largely eliminate their elevated genetic risk for lung cancer by quitting smoking- cutting their risk of lung cancer in half and delaying its onset by 7years for those who develop it.
|
27543155 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study was powered to identify strong risk loci for lung cancer in African Americans; we confirmed results previously reported in African Americans and other populations for two loci near plausible candidate genes, CHRNA5 and TERT, on 15q25.1 and 5p15.33 respectively, are associated with lung cancer.
|
27393504 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population.
|
27393504 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Sliding window haplotype analysis within chromosome 15, evaluating 4722250 haplotypes and pair-wise haplotype analysis identified that CHRNA5 rs588765-rs16969968 was the most significant haplotype associated with lung cancer risk (omnibus P = 8.35×10(-15) in discovery and 7.26×10(-14) in replication), and improved the prediction of case status over that provided by the individual SNPs rs16969968 or rs588765 (likelihood ratio test P = 0.006 for rs16969968 and 3.83×10(-14) for rs588765 in discovery, 0.009 for rs16969968 and 4.62×10(-13) for rs588765 in replication, compared with rs588765-rs16969968).
|
26282330 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis.
|
25873736 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We found the CHRNA5 rs16969968 polymorphism to be associated with the risk of lung cancer (AA vs GG: OR=1.60, 95%CI=1.51-1.71).
|
26434895 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The differences in risk level between Israeli Jews and non-Jews could not be explained by lung cancer genetic risk variants which were identified in GWAS (genes in the CHRNA5, TERT and CLPTM1L regions).
|
25924736 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Because the associations with lung disease remain after adjustment for self-reported smoking behaviors, it has been asserted that CHRNA5-CHRNA3-CHRNB4 variants increase COPD and lung cancer susceptibility independently of their effects on smoking.
|
25072098 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, no studies have investigated the association between CHRNA5 rs3841324, which has been proven to have the highest association with CHRNA5 mRNA expression, and the risk of other smoking-associated cancers, except lung cancer.
|
25329654 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic receptor related genes (CHRNB3, CHRNA6, and CHRNA5/A3/B4) previously reported to be associated with lung cancer risk and smoking behavior and 14 SNPs in the four 'control' genes (TERT, CLPTM1L, CYP1A1, and TP53), which were not reported in the smoking GWA studies.
|
25233467 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previously we found that variation in CYP2A6 and CHRNA5-CHRNA3-CHRNB4 combined to increase lung cancer risk in a case-control study in European American ever-smokers (n = 860).
|
23591849 |
2013 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the present hospital-based, case-control study, we determined whether polymorphism in rs503464 of CHRNA5 is associated with lung cancer risk in Chinese individuals.
|
23314339 |
2013 |