Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 AlteredExpression group BEFREE The transcription profile of CHRNA5 depleted MCF7 cells showed a significant positive correlation with that of A549 lung cancer cell line while exhibiting a negative association with the CHRNA5 co-expression profile obtained from Cancer Cell Line Encylopedia (CCLE). 30543688 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 Biomarker group BEFREE Our microarray results reveal that knockdown of the CHRNA5 gene encoding α5-nAChR significantly modulates key pathways including the cell cycle, DNA replication, pathway in cancer. 28878681 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 GeneticVariation group BEFREE These studies identify pharmacological tools from two distinct classes of drugs, antagonists and modifiers that are α5 and α5-D398N subtype selective that provide a means to characterize the role of the CHRNA5/A3/B4 gene cluster in smoking and cancer. 28045487 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 GeneticVariation group BEFREE Our data suggest that gene variance in the CHRNA5-CHRNA3-CHRNB4 cluster is associated with an increased risk of death, incidence of COPD and tobacco-related cancer in smokers. 26689306 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 GeneticVariation group BEFREE A case-control study of 866 ESCC patients and 952 healthy controls was performed to study the association of polymorphisms (rs667282 and rs3743073) in CHRNA5-A3-B4 with cancer risk using logistic regression models. 23844051 2013
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 GeneticVariation group BEFREE We examined the associations between the nicotinic acetylcholine receptor polymorphism (rs1051730) on chromosome 15q25 marking the gene cluster CHRNA3-CHRNB4-CHRNA5, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases in the general population. 21646606 2011
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 GeneticVariation group BEFREE Genome-wide association studies have provided evidence that common variation at 5p15.33 [telomerase reverse transcriptase (TERT)-cleft lip and palate transmembrane 1-like (CLPTM1L)], 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) influences lung cancer risk and cancer types with strong environmental risk factors. 19465454 2009