Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior.
|
31288250 |
2019 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Several genome-wide association and candidate gene studies have linked chromosome 15q24-q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease.
|
22438940 |
2012 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Several genome-wide association and candidate gene studies have linked chromosome 15q24-q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease.
|
22438940 |
2012 |
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Recent human genetic association studies have implicated the gene cluster CHRNA3-CHRNA5-CHRNB4 encoding the α3, α5, and β4 subunits of the nAChR in susceptibility to develop nicotine and alcohol dependence; however, their role in ethanol-mediated behaviors is unknown due to the lack of suitable and selective research tools.
|
21048701 |
2011 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Recent human genetic association studies have implicated the gene cluster CHRNA3-CHRNA5-CHRNB4 encoding the α3, α5, and β4 subunits of the nAChR in susceptibility to develop nicotine and alcohol dependence; however, their role in ethanol-mediated behaviors is unknown due to the lack of suitable and selective research tools.
|
21048701 |
2011 |
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
We also observed two SNPs associated with alcohol dependence, that is, rs615470 in CHRNA5 (OR=0.77, P=0.0006) and rs578776 (OR=0.78, P=0.001).
|
20485328 |
2010 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
We also observed two SNPs associated with alcohol dependence, that is, rs615470 in CHRNA5 (OR=0.77, P=0.0006) and rs578776 (OR=0.78, P=0.001).
|
20485328 |
2010 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
CTD_human |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |
Alcoholic Intoxication, Chronic
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
The transcription profile of CHRNA5 depleted MCF7 cells showed a significant positive correlation with that of A549 lung cancer cell line while exhibiting a negative association with the CHRNA5 co-expression profile obtained from Cancer Cell Line Encylopedia (CCLE).
|
30543688 |
2018 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among them, TP63 (3q28), RP11-650L12.2 (15q25.1) and CHRNA5 (15q25.1) were located in known lung cancer susceptibility loci.
|
29193083 |
2018 |
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
CHRNA5/CHRNA3/CHRNB4 gene cluster is located on chromosome 15q25.1 and was reported to be associated with risk of lung cancer.
|
29416783 |
2018 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Surprisingly, the most convincing association (a nicotinic acetylcholine receptor <i>CHRNA5-A3-B4</i> gene cluster in nicotine dependence), with a unique attributable risk of 14%, was detected through a genome-wide association study (GWAS) on lung cancer, although lung cancer has a low heritability.
|
29302221 |
2017 |
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies (GWAS) show that CHRNA5 gene encoding α5-nAChR is especially relevant to lung cancer.
|
28750889 |
2017 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent.
|
27072204 |
2016 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.
|
26689306 |
2016 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CPD was found to be a nominally significant effect modifier between SNP and lung cancer for six SNPs, including CHRNA5 rs2036527[A](betaSNP*CPD = - 0.017, p = 0.0061, corrected p = 0.054), which was associated with CPD in a previous genome-wide meta-analysis of African-Americans.
|
26981579 |
2016 |
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) in the cholinergic nicotinic receptor subunit genes on chromosome 15q25.1, including CHRNA3, CHRNB4 and CHRNA5, are well-established biomarkers of chronic obstructive pulmonary disease (COPD) and lung cancer.
|
27462996 |
2016 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Smokers with high-risk CHRNA5 genotypes, on average, can largely eliminate their elevated genetic risk for lung cancer by quitting smoking- cutting their risk of lung cancer in half and delaying its onset by 7years for those who develop it.
|
27543155 |
2016 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study was powered to identify strong risk loci for lung cancer in African Americans; we confirmed results previously reported in African Americans and other populations for two loci near plausible candidate genes, CHRNA5 and TERT, on 15q25.1 and 5p15.33 respectively, are associated with lung cancer.
|
27393504 |
2016 |