NLRP3, NLR family pyrin domain containing 3, 114548

N. diseases: 805; N. variants: 74
Disease: Hidradenitis Suppurativa ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0162836
Disease: Hidradenitis Suppurativa
Hidradenitis Suppurativa 		0.330 Biomarker disease BEFREE C3a and C5a are associated with activation of the NLRP3 inflammasome, implicated in the inflammatory drive in HS. 31688984 2020
CUI: C0162836
Disease: Hidradenitis Suppurativa
Hidradenitis Suppurativa 		0.330 AlteredExpression disease BEFREE In skin keratinocytes, lymphocytes, and monocytes, but not in neutrophils, P2X7R and NLRP3 protein expression was significantly increased in HS versus the HC group. 31454821 2019
CUI: C0162836
Disease: Hidradenitis Suppurativa
Hidradenitis Suppurativa 		0.330 AlteredExpression disease BEFREE Furthermore, in HS, there is dysregulated function of other immune players closely associated with macrophage function including: matrix metalloproteases (MMP) 2 and 9 overexpression, toll-like receptor upregulation, impaired Notch signalling, NLRP3 inflammasome upregulation, and dysregulated keratinocyte function. 28656364 2017
CUI: C0162836
Disease: Hidradenitis Suppurativa
Hidradenitis Suppurativa 		0.330 Biomarker disease CTD_human Pyoderma gangrenosum and its syndromic forms: evidence for a link with autoinflammation. 27106250 2016