C1QTNF1, C1q and TNF related 1, 114897

N. diseases: 27; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.030 Biomarker disease BEFREE Our data supports CTRP1 and CTRP12 as potential novel biomarkers for the prediction and early diagnosis of T2DM. 28207876 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.030 Biomarker disease BEFREE C1qTNF-related protein 1 (CTRP1) is independently associated with type 2 diabetes. 28674284 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.030 Biomarker disease BEFREE CTRP1 is a novel adipokine associated with T2DM in humans. 24827430 2014
CUI: C0028754
Disease: Obesity
Obesity
0.020 Biomarker disease BEFREE C1q/tumour necrosis factor-related protein 1 (CTRP1) is a new adipokine with multiple vascular and metabolic effects and may modulate the association between obesity and vascular diseases. 31198543 2019
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.020 AlteredExpression disease BEFREE At baseline, obesity, the metabolic syndrome, type 2 diabetes, and non-alcoholic fatty liver disease were significantly associated with increased CTRP1 (all p-values ≤0.001). 31051410 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.020 AlteredExpression disease BEFREE We measured CTRP1 serum levels in 539 patients undergoing coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). 31051410 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.020 AlteredExpression disease BEFREE Serum levels of CTRP1 were significantly higher in CAD patients than in controls (17.24 ± 1.07 versus 9.31 ± 0.56 ng/mL), and CTRP1 levels increased with increasing severity of CAD. 31081425 2019
CUI: C0011175
Disease: Dehydration
Dehydration
0.020 Biomarker phenotype BEFREE Mice lacking Ctrp1 fail to maintain normotension under dehydration conditions, resulting in hypotension, suggesting that CTRP1 is an essential protein for maintaining blood pressure homeostasis. 30463644 2018
CUI: C0011175
Disease: Dehydration
Dehydration
0.020 Biomarker phenotype BEFREE The increase in CTRP1 under dehydration conditions was mediated by glucocorticoids, and the antagonist mifepristone prevented the increase in CTRP1 and attenuated BP recovery. 30030219 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.020 Biomarker disease BEFREE Our results demonstrated that C1QTNF1 improves cardiac function and inhibits cardiac hypertrophy and fibrosis by increasing and activating AMPKa, suggesting that C1QTNF1 could be a therapeutic target for cardiac hypertrophy and heart failure. 29733904 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.020 Biomarker group BEFREE Patients with hypertension also display higher circulating CTRP1 levels, compared to healthy individuals, indicating that excessive CTRP1 may affect development of hypertension. 30463644 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.020 AlteredExpression disease BEFREE There were no differences in the CTRP1 levels in cardiomyocytes between the CHF group and the non-CHF group. 28810263 2017
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.020 Biomarker disease BEFREE Hence, various roles in metabolic pathways can link CTRP1 to NAFLD pathogenesis. 28212710 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.020 Biomarker group BEFREE As CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. 18171693 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.020 AlteredExpression group LHGDN As CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. 18171693 2008
CUI: C0028754
Disease: Obesity
Obesity
0.020 Biomarker disease BEFREE As CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. 18171693 2008
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.010 Biomarker disease BEFREE CTRP1 correlated strongly with markers of inflammatory response, renal function, liver damage and cholestasis. 31083558 2019
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.010 AlteredExpression disease BEFREE Association of C1q/TNF-related protein-1 (CTRP1) serum levels with coronary artery disease. 31081425 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.010 AlteredExpression disease BEFREE Association of C1q/TNF-related protein-1 (CTRP1) serum levels with coronary artery disease. 31081425 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.010 GeneticVariation disease BEFREE The genetic alterations of CTRP1 occurred at a low rate in GBM (2 of 591 sequenced cases/patients, 0.33%). 31183364 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.010 AlteredExpression group BEFREE High CTRP1 levels may have a renal protective role since they were associated with slower kidney disease progression. 31198543 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.010 AlteredExpression disease BEFREE CTRP1 levels were significantly higher in ICU patients with sepsis. 31083558 2019
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases
0.010 Biomarker group BEFREE C1q/tumour necrosis factor-related protein 1 (CTRP1) is a new adipokine with multiple vascular and metabolic effects and may modulate the association between obesity and vascular diseases. 31198543 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.010 AlteredExpression phenotype BEFREE Moreover, CTRP1 knockdown inhibited CCL2 expression, and CCL2 overexpression reversed the inhibition of cell proliferation and migration induced by CTRP1 knockdown, suggesting that CTRP1 promoted tumor progression by regulating CCL2 expression. 31183364 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.010 AlteredExpression disease BEFREE CTRP1 levels were significantly higher in ICU patients with sepsis. 31083558 2019