Diabetes Mellitus
|
0.190 |
GeneticVariation
|
group |
BEFREE |
In current study two SNPs rs662799 risk allele G (P = 0.03) and rs3135506 risk allele C (P = 0.05) of APOA5 were found to be associated with significant higher risk of triglyceride levels, irrespective of age, sex, obesity, diabetes, hypertension and smoking.
|
24402875 |
2014 |
Diabetes Mellitus
|
0.190 |
GeneticVariation
|
group |
BEFREE |
Population studies conducted in various countries have demonstrated an association between single nucleotide polymorphisms (SNPs) in ApoA5 and the increased risk to cardiovascular disease and metabolic syndrome (including diabetes and obesity).
|
23000317 |
2013 |
Diabetes Mellitus
|
0.190 |
GeneticVariation
|
group |
BEFREE |
We investigated the association between circulating triglyceride levels, the apolipoprotein A-V (ApoA5) -1131T>C single nucleotide polymorphism and brachial-ankle pulse wave velocity (baPWV) by examining data from 4421 subjects aged 18-74 years who were recruited from the Chinese population. baPWV was significantly associated with the levels of circulating triglycerides after adjusting for age, sex, body mass index (BMI), systolic blood pressure, heart rate, waist-to-hip ratio, antihypertensive treatment and diabetes mellitus status.
|
22648266 |
2013 |
Diabetes Mellitus
|
0.190 |
GeneticVariation
|
group |
BEFREE |
The APOA5-1131 T>C variant enhances the association between RBP4 and hypertriglyceridemia in diabetes.
|
19765959 |
2010 |
Diabetes Mellitus
|
0.190 |
GeneticVariation
|
group |
BEFREE |
APOA5 -1131C allele was associated with an increased risk of DM (OR, 1.61 [95% confidence interval {CI}, 1.23-2.10]; P < .001) after adjustment for the above confounders.
|
20303129 |
2010 |
Diabetes Mellitus
|
0.190 |
Biomarker
|
group |
BEFREE |
Plasma HDL-C levels were associated with sex (higher in females), BMI (inversely), smoking (lower in smokers), DM (lower in those with DM) and SNPs in APOA5, APOC2, CETP, LPL and LIPC (each q <or=0.01).
|
19878569 |
2009 |
Diabetes Mellitus
|
0.190 |
GeneticVariation
|
group |
BEFREE |
We found that: (i) genotypes, including those of APOA5 S19W, APOA5 -1131T > C, APOE, GCKR, TRIB1 and TBL2/MLXIPL, were significantly associated with severe HTG; (ii) odds ratios for these genetic variables were significant in both univariate and multivariate regression analyses, irrespective of the presence or absence of diabetes or obesity; (iii) a significant fraction-about one-quarter-of the explained variation in disease status was associated with these genotypes.
|
18596051 |
2008 |
Diabetes Mellitus
|
0.190 |
GeneticVariation
|
group |
LHGDN |
The frequency of the APOA5-1131C allele in DM patients was significantly higher than that of the control group (0.430 vs 0.296, P = 0.006).
|
17548321 |
2007 |
Diabetes Mellitus
|
0.190 |
Biomarker
|
group |
BEFREE |
Recent findings indicate that APOA5 could also influence cholesterol homeostasis and probably play a role in hypertriglyceridemia associated with diabetes and inflammation.
|
16448983 |
2006 |
Diabetes Mellitus
|
0.190 |
Biomarker
|
group |
HPO |
|
|
|