Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression disease BEFREE ApoA1, ApoA5, Cyp2c37, Cyp2J5, Cyp2b9 and Cyp2b10 were differently expressed after rosiglitazone treatment, which may be accountable for affecting cardiovascular outcomes and glycemic control in T2DM. 30783475 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Relationship of Serum Apolipoprotein A-V Levels, Oxidative Stress and Inflammatory Biomarkers with Hypertriglyceridemia in Type 2 Diabetes Mellitus. 28848612 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE In high cardiovascular risk patients (e.g., patients with metabolic syndrome or type 2 diabetes), APOA5 variants elevate TG levels and shift the entire lipoprotein subclass distribution toward atherogenic dyslipidemia. 28500476 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE We genotyped the APOA5 -1131 T > C polymorphism in 203 Korean individuals with IFG or new-onset type 2 diabetes for the TT (n = 91), TC (n = 98), and CC (n = 14) alleles. 24775272 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE The present meta-analysis suggests that the APOA5 -1131T/C polymorphism is associated with an increased T2DM risk in Asian population. 24586566 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE We genotyped the APOA5 -1131 T > C in individuals with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes, who were randomly assigned to either a group ingesting whole grain and legume meals daily or a control group for 12 weeks. 24690159 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE APOA5 -1131T/C polymorphism was shown to be significantly associated with of type 2 diabetes (T2D, OR = 1.27, 95% CI = 1.03-1.57, P = 0.03). 23922971 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE Our results suggest that hypertriglyceridemia in patients with T2DM is not likely to be associated with the APOA5 -1131T>C polymorphism. 23919616 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE This study aimed to identify the frequencies of the APOA5 -1131T>C and SW19 polymorphisms and evaluate their effects on lipid levels in patients with type 2 diabetes. 22350263 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE PON1 and APOA5 polymorphisms may serve as biomarkers in the South Indian population to identify T2DM patients who are at risk of developing CAD. 21438666 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE These results suggest that in T2D APOA5 polymorphisms contribute to modulate dyslipidemia. 18468520 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE While the variable size effects of the two APOA5 SNPs on TG levels may result from ethnically different gene-gene or gene-environment interactions, APOA5 and APOC3 variants did not affect parameters of T2D. 17197160 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE In prospective analysis, with the caveat that numbers were small, APOA5 genotypes do not appear to have an impact on risk of development of type 2 diabetes. 16917759 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE APOA5 c.553G>T polymorphism is not significantly associated with susceptibility to type 2 diabetes mellitus, but is associated with plasma triglyceride and low-density lipoprotein cholesterol levels. 17087641 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Plasma APOA5 concentration was measured by ELISA in 215 subjects with type 2 diabetes, who were taken from the Diabetes Atorvastatin Lipid-lowering Intervention (DALI) study, a 30-week randomised, double-blind, placebo-controlled study, and given atorvastatin 10 mg or 80 mg daily. 16752169 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE The frequency of the APOA5 -1131C allele in the DM+CHD group was significantly higher than that of control subjects (37.2% vs. 27.7%, p=0.021). 16006256 2005
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE Association of SNP3 polymorphism in the apolipoprotein A-V gene with plasma triglyceride level in Tunisian type 2 diabetes. 15636639 2005