|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Diarrhea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
(c) For any other combination of GPCR and skin disease, we found positive/negative mixed results.
|
30339292 |
2019 |
|
Endothelial dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Endothelial dysfunction is induced by inflammatory mediators including multiple G protein-coupled receptor (GPCR) agonists.
|
30760523 |
2019 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
GPCR genes implicated in asthma endophenotypes include variants of the cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2), and prostaglandin D2 receptors (PTGDR and CRTH2), thromboxane A2 receptor (TBXA2R), beta2-adrenergic receptor (ADRB2), chemokine receptor 5 (CCR5), and the G protein-coupled receptor associated with asthma (GPRA).
|
17154652 |
2006 |
|
Well Differentiated Pancreatic Endocrine Tumor
|
0.020 |
Biomarker
|
disease |
BEFREE |
GPCR somatostatin receptor extracellular loop 2 is a key ectodomain for making subtype-selective antibodies with agonist-like activities in the pancreatic neuroendocrine tumor BON cell line.
|
20531241 |
2010 |
|
Islet Cell Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
GPCR somatostatin receptor extracellular loop 2 is a key ectodomain for making subtype-selective antibodies with agonist-like activities in the pancreatic neuroendocrine tumor BON cell line.
|
20531241 |
2010 |
|
Cone-Rod Dystrophy 2
|
0.010 |
Biomarker
|
disease |
BEFREE |
GPCR kinase 2-interacting protein-1 (GIT1) is a scaffold protein that plays an important role in cell adaptation, proliferation, migration, and differentiation; however, the role of GIT1 in the regulation of neuronal death after spinal cord injury remains obscure.
|
29912587 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
GPCR mediator β-arrestins (β-arr1 and β-arr2) regulate a variety of physiologic and pathologic processes, including hepatocellular carcinogenesis.
|
30216111 |
2019 |
|
Malignant neoplasm of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer.
|
31289610 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer.
|
31289610 |
2019 |
|
Thyroid carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer.
|
31289610 |
2019 |
|
Meningeal melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset.
|
31663661 |
2019 |
|
Graves Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
A diagnostic biomarker for Graves' disease is the presence of immunoglobulins which bind to, and stimulate, the thyroid stimulating hormone receptor (TSHR), a G-protein coupled receptor (GPCR).
|
23039881 |
2012 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
A number of GPCR-targeting asthma drug candidates are also in different stages of development.
|
31767622 |
2020 |
|
Essential Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
A two-mode network model based on the potential biomarkers demonstrated that hemostasis and GPCR ligand binding pathway were key pathways contributing to EH.
|
30110599 |
2018 |
|
Tumor Initiation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrant G protein-coupled receptor (GPCR) expression and activation has been linked to tumor initiation, progression, invasion, and metastasis.
|
29348172 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrant G protein-coupled receptor (GPCR) expression and activation has been linked to tumor initiation, progression, invasion, and metastasis.
|
29348172 |
2018 |
|
Usher Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria.
|
21124978 |
2010 |
|
POLYMICROGYRIA, BILATERAL FRONTOPARIETAL
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria.
|
21124978 |
2010 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Allosteric receptor-receptor interactions in GPCR-receptor tyrosine kinases (RTKs) heteromers and postulated ion channel receptor-RTK heteromers-like, for example, AMPA-NMDA-TrkB heteromers may lead to moonlighting of the participating GPCR and RTK protomers altering, for example, the pattern of the five major signaling pathways of the RTKs favoring MAPK and/or mTOR signaling with high relevance for neurodegenerative processes and depression induced atrophy of neurons.
|
21698749 |
2011 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Allosteric receptor-receptor interactions in GPCR-receptor tyrosine kinases (RTKs) heteromers and postulated ion channel receptor-RTK heteromers-like, for example, AMPA-NMDA-TrkB heteromers may lead to moonlighting of the participating GPCR and RTK protomers altering, for example, the pattern of the five major signaling pathways of the RTKs favoring MAPK and/or mTOR signaling with high relevance for neurodegenerative processes and depression induced atrophy of neurons.
|
21698749 |
2011 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Allosteric receptor-receptor interactions in GPCR-receptor tyrosine kinases (RTKs) heteromers and postulated ion channel receptor-RTK heteromers-like, for example, AMPA-NMDA-TrkB heteromers may lead to moonlighting of the participating GPCR and RTK protomers altering, for example, the pattern of the five major signaling pathways of the RTKs favoring MAPK and/or mTOR signaling with high relevance for neurodegenerative processes and depression induced atrophy of neurons.
|
21698749 |
2011 |
|
Gross obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although MRAP2 has been shown to regulates a number of GPCRs involved in metabolism, the key neurons responsible for the phenotype of gross obesity in MRAP2 deficient animals are unclear.
|
30352741 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although viral GPCRs are conserved in all gamma herpesviruses, kGPCR potently activated downstream signaling and induced tumor formation in nude mouse, whereas γHV68 GPCR failed to do so.
|
26107716 |
2015 |