|
Chondrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RESULTS Results showed that the expression of ClC-3 chloride channel in the normal chondrocyte was thinner, since it showed distinct differentiation among chondrosarcoma specimens.
|
31281178 |
2019 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes.
|
30468668 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous work has shown significant alleviation of type 2 diabetes in Clcn3 knockout (Clcn3<sup>-/-</sup>) mice.
|
31165783 |
2019 |
|
Hyperalgesia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Cltx causes hyperalgesia and decreased expression of ClC-3 in OVX rats.
|
31787875 |
2019 |
|
Lymphatic Metastasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Intrathecal Cltx to OVX and OVX + SNI rats was administered for 4 consecutive days (days 7-10 after SNI) to further determine the contribution of ClC-3 to neuropathic pain.
|
31787875 |
2019 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study we investigated the role of Clcn3 in high-fat diet (HFD)-induced obesity and ATM inflammation.
|
31165783 |
2019 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Blocking CLC-3 Cl<sup>-</sup> channels by gluconate inhibits seizure activity both in neonatal brain slices and in neonatal animals with in vivo EEG recordings.
|
31088565 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ClC-3 was highly expressed in the P-glycoprotein (P-gp)-dependent human lung adenocarcinoma cell line (A549)/paclitaxel (PTX) and the human breast carcinoma cell line (MCF-7)/doxorubicin (DOX) resistant cells.
|
30230544 |
2019 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ClC-3 mRNA and protein expression in SCC tissues from cervical squamous cell carcinoma patients was significantly upregulated, and no significant difference was noted between the matched paracarcinoma fresh tissue from the same patients and non-cervical cancer patients.
|
30905432 |
2019 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this research, we explore the ClC-3 expression in cervical carcinoma and its underlying clinical significance, trying to illuminate ClC-3 probable function in the neoplasm malignant behavior, development and prognosis.
|
30636929 |
2019 |
|
Impaired cognition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expressions of CLC-3 and TGF- beta RII with cognitive impairment were observed in diabetic rats.
|
30468668 |
2019 |
|
Human papilloma virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
|
Diabetic encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The CLC-3 might be modulated by TGF- beta /TGF- beta RII signaling pathway during the development of DE.
|
30468668 |
2019 |
|
Limb ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice lacking of ClC-3 exhibited reduced blood flow recovery and neovascularization in ischemic muscles 7 and 14 days after hind limb ischemia.
|
31679624 |
2019 |
|
Hypertrophic Cardiomyopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also provide Clcn3 as a direct target of miR-1-3p which sheds light on the mechanism of HCM.
|
29885652 |
2018 |
|
Endotoxemia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Therefore, the regulation of intestinal tissue integrity by ClC-3 is crucial for maintaining LPS-induced survival in mice with endotoxemia.
|
29972266 |
2018 |
|
Asthenozoospermia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Spermatozoa from men with asthenozoospermia demonstrated lower volume regulating capacity, mobility, and ClC-3 expression levels (especially in the neck) than did normal spermatozoa.
|
27270342 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, higher expression of CLC-3 was correlated with deeper tumor invasion (P = 0.006) and increased lymph node metastasis (P = 0.016), and knockdown of CLC-3 inhibited cell proliferation and migration in vitro.
|
30217218 |
2018 |
|
HER2-positive carcinoma of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our results demonstrate that intracellular Cl<sup>-</sup> regulation by ANO1/ClC-3 participates in HER2 transcription, mediating the PI3K/AKT/mTOR and/or STAT3 signaling pathway(s) in HER2-positive breast cancer cells, and support the potential of ANO1/ClC-3 blockers as therapeutic options for patients with resistance to anti-HER2 therapies.
|
29949674 |
2018 |
|
Pneumonitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The liver and lung inflammations in mice with ClC-3 deletion were significantly less than those in wild-type mice, and the levels of TNF-α and MIP-2 in serum were lower than those of wild-type mice.
|
29972266 |
2018 |
|
Dysmenorrhea
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
ClC-3 expression level was well-correlated to the clinical characteristics and symptoms of endometriosis patients, including infertility, dysmenorrhea, chronic pelvic pain, dyspareunia and diameter of endometriosis lesion.
|
26965430 |
2016 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
An ITALIC! in vitro investigation of the effect of ClC-3 on the migration and invasion of ectopic ESCs from patients with endometriosis.
|
26965430 |
2016 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, cytoplasmic ClC-3 plays an active and key role in tumor metastasis and may be a valuable prognostic biomarker and a therapeutic target to prevent tumor spread.
|
25537517 |
2015 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we define the following intracellular mechanisms regulated by 1,25D3 that are associated with recovery of phagocytosis and consistent with the selectivity of BDC: 1) 1,25D3 potentiates a 4,4-diisothiocyanostilbene-2,2-disulfonic acid-sensitive chloride channel (i.e., ClC-3) currents in both Type I and II AD macrophages, but curcumin only potentiates the currents in Type I cells; 2) 1,25D3 is particularly effective in upregulating ClC-3 mRNA expression in Type II peripheral blood mononuclear cells (PBMCs) while both 1,25D3 and the BDC analog, C180, upregulate VDR mRNA, repressed by Aβ42 in Type II PBMCs; and 3) 1,25D3-induced Aβ42 phagocytosis is attenuated by the calcium-dependent ClC-3 blocker, inositol 3,4,5,6-tetraphosphate (IP4), in both AD Types and by the MEK1/2 inhibitor U0126 only in Type II macrophages.
|
22207005 |
2012 |