Stomach Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
|
21364753 |
2011 |
Child Development Disorders, Pervasive
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Chloride channel-3 (CLC-3) has been reported to promote the proliferation and invasion in various tumors, yet little is known about its role in gastric cancer.
|
29795988 |
2018 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
BACKGROUND Recently, ClC-3 chloride channel expression has been noted to be high in some tumors.
|
31281178 |
2019 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
ClC-3 is a type of chloride channel that has multiple functions in tumorigenesis and tumor growth, and can be blocked by DIDS (4,4'-diisothiocyanostilbene-2,2'-disulfonic acid).
|
29749557 |
2018 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Moreover, up-regulation of CIC-3 markedly correlated with tumor size and overall prognosis, suggesting that CIC-3 expression could predict both tumor size and overall prognosis in hepatocarcinoma.
|
30678806 |
2019 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Chloride channel-3 (ClC-3) is over-expressed in a variety of cancers and involves multiple tumor biological events.
|
31606620 |
2019 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Together, our data suggest that upregulation of ClC-3 by IGF-1 contributes to cell proliferation and tumor growth in breast cancer, and ClC-3 deficiency suppresses cell proliferation and tumor growth via the IGF/IGF receptor/ERK pathway.
|
29963105 |
2018 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
High-grade expression of cytoplasmic ClC-3 predicted poor survival in cancer patients.
|
25537517 |
2015 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
ClC-3 may be a new target for cancer therapies.
|
18359479 |
2008 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In this research, we explore the ClC-3 expression in cervical carcinoma and its underlying clinical significance, trying to illuminate ClC-3 probable function in the neoplasm malignant behavior, development and prognosis.
|
30636929 |
2019 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Chloride channel-3 mediates multidrug resistance of cancer by upregulating P-glycoprotein expression.
|
30230544 |
2019 |
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
High-grade expression of cytoplasmic ClC-3 predicted poor survival in cancer patients.
|
25537517 |
2015 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
ClC-3 may be a new target for cancer therapies.
|
18359479 |
2008 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
In this research, we explore the ClC-3 expression in cervical carcinoma and its underlying clinical significance, trying to illuminate ClC-3 probable function in the neoplasm malignant behavior, development and prognosis.
|
30636929 |
2019 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Chloride channel-3 mediates multidrug resistance of cancer by upregulating P-glycoprotein expression.
|
30230544 |
2019 |
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The ClC-3 chloride channels in cardiovascular disease.
|
21602838 |
2011 |
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes.
|
30468668 |
2019 |
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
This review will highlight the major findings and recent advances in the study of ClC-3 Cl(-) channels in the cardiovascular system and discuss their important roles in cardiac and vascular remodeling during hypertension, myocardial hypertrophy, ischemia/reperfusion, and heart failure.
|
21602838 |
2011 |
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, we have shown that heterologous expression of ClC-3 in either Chinese hamster ovary (CHO-K1) or human hepatoma (Huh-7) cells results in the formation of large, acidic vesicular structures within cells.
|
11997263 |
2002 |
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, cytoplasmic ClC-3 plays an active and key role in tumor metastasis and may be a valuable prognostic biomarker and a therapeutic target to prevent tumor spread.
|
25537517 |
2015 |
Disease Exacerbation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
|
21364753 |
2011 |
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic studies suggested that canonical TGF-β/Smad signaling pathway is involved in CLC-3-induced gastric cancer cells proliferation, migration and invasion.
|
29795988 |
2018 |
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Silencing endogenous CLC-3 with ShCLC-3 adenovirus significantly decreases volume-regulated chloride currents, inhibits the nuclear translocation of p65 subunit of Nuclear Factor-κB (NF-κB), decreases transcriptional activity of NF-κB, reduces MMP-3 and MMP-9 expression and decreases glioma cell migration and invasion.
|
28969029 |
2017 |