|
Impaired cognition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expressions of CLC-3 and TGF- beta RII with cognitive impairment were observed in diabetic rats.
|
30468668 |
2019 |
|
Lymphatic Metastasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
|
Human papilloma virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The AQP-3 water channel and the ClC-3 chloride channel coordinate the hypotonicity-induced swelling volume in nasopharyngeal carcinoma cells.
|
25450461 |
2014 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to explore the molecular mechanisms underlying the antitumor effect of silencing ClC-3 in breast cancer.
|
29963105 |
2018 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to explore the molecular mechanisms underlying the antitumor effect of silencing ClC-3 in breast cancer.
|
29963105 |
2018 |
|
Diabetic encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The CLC-3 might be modulated by TGF- beta /TGF- beta RII signaling pathway during the development of DE.
|
30468668 |
2019 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ClC-3 chloride channel protein is a downstream target of cyclin D1 in nasopharyngeal carcinoma cells.
|
23270726 |
2013 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The ClC-3 chloride channels in cardiovascular disease.
|
21602838 |
2011 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes.
|
30468668 |
2019 |
|
Nasal Polyps
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
TGF-beta and IL-4 may modulate the expression of CLC-2 and CLC-3 in CRSsNP.
|
17882904 |
2007 |
|
Glioma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest CLC-3 promotes the aggressiveness of glioma at least in part through nuclear factor-κB pathway, and might be a novel prognostic biomarker and therapeutic target for glioma.
|
28969029 |
2017 |
|
Glioma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Suppression of chloride channel 3 expression facilitates sensitivity of human glioma U251 cells to cisplatin through concomitant inhibition of Akt and autophagy.
|
23408563 |
2013 |
|
Asthenozoospermia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Spermatozoa from men with asthenozoospermia demonstrated lower volume regulating capacity, mobility, and ClC-3 expression levels (especially in the neck) than did normal spermatozoa.
|
27270342 |
2018 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Silencing endogenous CLC-3 with ShCLC-3 adenovirus significantly decreases volume-regulated chloride currents, inhibits the nuclear translocation of p65 subunit of Nuclear Factor-κB (NF-κB), decreases transcriptional activity of NF-κB, reduces MMP-3 and MMP-9 expression and decreases glioma cell migration and invasion.
|
28969029 |
2017 |
|
Chondrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RESULTS Results showed that the expression of ClC-3 chloride channel in the normal chondrocyte was thinner, since it showed distinct differentiation among chondrosarcoma specimens.
|
31281178 |
2019 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Pharmacological modulation of ClC-3 may provide a deep understanding in antiestrogen treatment of breast cancer patients.
|
28419445 |
2018 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Pharmacological modulation of ClC-3 may provide a deep understanding in antiestrogen treatment of breast cancer patients.
|
28419445 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous work has shown significant alleviation of type 2 diabetes in Clcn3 knockout (Clcn3<sup>-/-</sup>) mice.
|
31165783 |
2019 |
|
Vascular inflammations
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our previous study found that ClC-3 chloride channel functioned differently in the vascular and intestinal inflammation, the loss of ClC-3 reduced vascular inflammation but exacerbated intestinal inflammation.
|
29972266 |
2018 |
|
Nasopharyngeal carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrated that the selective antitumor activities of DHA in NPC may occur through the specific activation of the CLC-3 Cl<sup>-</sup> channel, leading to Cl<sup>-</sup> efflux, and induced AVD, then led to [Ca<sup>2+</sup> ]<sub>i</sub> accumulation and caspase-3 activation, and finally induced apoptosis.
|
30171707 |
2018 |
|
Nasopharyngeal carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nevertheless, ClC-3 knockdown had little effect on ROS levels, indicating that ROS acted upstream of ClC-3 and that both ROS and ClC-3 participated in EBSS-induced autophagy regulation in CNE-2Z.
|
30992317 |
2019 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Moreover, up-regulation of CIC-3 markedly correlated with tumor size and overall prognosis, suggesting that CIC-3 expression could predict both tumor size and overall prognosis in hepatocarcinoma.
|
30678806 |
2019 |