Malignant neoplasm of stomach
|
0.320 |
Biomarker
|
disease |
CTD_human |
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
|
21364753 |
2011 |
Stomach Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
|
21364753 |
2011 |
Disease Exacerbation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
|
21364753 |
2011 |
mixed gliomas
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of voltage-gated chloride channels in human glioma cells.
|
12843258 |
2003 |
Malignant Glioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of voltage-gated chloride channels in human glioma cells.
|
12843258 |
2003 |
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
|
21364753 |
2011 |
Neuronal Ceroid-Lipofuscinoses
|
0.210 |
Biomarker
|
disease |
MGD |
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.
|
15504734 |
2005 |
Neuronal Ceroid-Lipofuscinoses
|
0.210 |
Biomarker
|
disease |
MGD |
These results indicated that the neurodegeneration observed in the Clcn3-/- mice was caused by an abnormality in the machinery which degrades the cellular protein and was associated with the phenotype of neuronal ceroid lipofuscinosis (NCL).
|
12059962 |
2002 |
Neuronal Ceroid-Lipofuscinoses
|
0.210 |
Biomarker
|
disease |
BEFREE |
These results indicated that the neurodegeneration observed in the Clcn3-/- mice was caused by an abnormality in the machinery which degrades the cellular protein and was associated with the phenotype of neuronal ceroid lipofuscinosis (NCL).
|
12059962 |
2002 |
Late-Infantile Neuronal Ceroid Lipfuscinosis
|
0.200 |
Biomarker
|
disease |
MGD |
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis.
|
12059962 |
2002 |
Late-Infantile Neuronal Ceroid Lipfuscinosis
|
0.200 |
Biomarker
|
disease |
MGD |
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.
|
15504734 |
2005 |
Adult Neuronal Ceroid Lipofuscinosis
|
0.200 |
Biomarker
|
disease |
MGD |
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis.
|
12059962 |
2002 |
Adult Neuronal Ceroid Lipofuscinosis
|
0.200 |
Biomarker
|
disease |
MGD |
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.
|
15504734 |
2005 |
Juvenile Neuronal Ceroid Lipofuscinosis
|
0.200 |
Biomarker
|
disease |
MGD |
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.
|
15504734 |
2005 |
Juvenile Neuronal Ceroid Lipofuscinosis
|
0.200 |
Biomarker
|
disease |
MGD |
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis.
|
12059962 |
2002 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Chloride channel-3 (CLC-3) has been reported to promote the proliferation and invasion in various tumors, yet little is known about its role in gastric cancer.
|
29795988 |
2018 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
ClC-3 is a type of chloride channel that has multiple functions in tumorigenesis and tumor growth, and can be blocked by DIDS (4,4'-diisothiocyanostilbene-2,2'-disulfonic acid).
|
29749557 |
2018 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Together, our data suggest that upregulation of ClC-3 by IGF-1 contributes to cell proliferation and tumor growth in breast cancer, and ClC-3 deficiency suppresses cell proliferation and tumor growth via the IGF/IGF receptor/ERK pathway.
|
29963105 |
2018 |
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic studies suggested that canonical TGF-β/Smad signaling pathway is involved in CLC-3-induced gastric cancer cells proliferation, migration and invasion.
|
29795988 |
2018 |
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The purpose of this study was to evaluate whether ClC-3 influences the migration and invasion of cervical squamous cell carcinoma cells and its possible mechanisms.
|
30905432 |
2019 |
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, higher expression of CLC-3 was correlated with deeper tumor invasion (P = 0.006) and increased lymph node metastasis (P = 0.016), and knockdown of CLC-3 inhibited cell proliferation and migration in vitro.
|
30217218 |
2018 |
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
An ITALIC! in vitro investigation of the effect of ClC-3 on the migration and invasion of ectopic ESCs from patients with endometriosis.
|
26965430 |
2016 |
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to explore the molecular mechanisms underlying the antitumor effect of silencing ClC-3 in breast cancer.
|
29963105 |
2018 |
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
In the present study, we showed the involvement of intracellular organelle ClC-3 Cl<sup>-</sup> /H<sup>+</sup> transporter in HER2 transcription in breast cancer MDA-MB-453 cells.
|
29949674 |
2018 |
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
To assess the roles of CLCN3 in breast cancer, we next performed three-dimensional (3D) spheroid proliferation analyses using MCF10A-ErbB2 cells treated with MCF10A-neo-derived exosomes or CLCN3 shRNA stably expressing SKBR3 and MDA-MB-453 breast cancer cells.
|
31608175 |
2019 |