Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous work has shown significant alleviation of type 2 diabetes in Clcn3 knockout (Clcn3<sup>-/-</sup>) mice.
|
31165783 |
2019 |
Diabetic encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The CLC-3 might be modulated by TGF- beta /TGF- beta RII signaling pathway during the development of DE.
|
30468668 |
2019 |
Disease Exacerbation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
|
21364753 |
2011 |
Dysmenorrhea
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
ClC-3 expression level was well-correlated to the clinical characteristics and symptoms of endometriosis patients, including infertility, dysmenorrhea, chronic pelvic pain, dyspareunia and diameter of endometriosis lesion.
|
26965430 |
2016 |
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
An ITALIC! in vitro investigation of the effect of ClC-3 on the migration and invasion of ectopic ESCs from patients with endometriosis.
|
26965430 |
2016 |
Endotoxemia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Therefore, the regulation of intestinal tissue integrity by ClC-3 is crucial for maintaining LPS-induced survival in mice with endotoxemia.
|
29972266 |
2018 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A total of 14 clones could be matched to known genes and were categorized into four groups: A) transcription factors: prothymosin, CA150, p78 serine/threonine kinase, IL-1beta-stimulating gene, glucocorticoid receptor, MLN64/CAB1, gastrin-binding protein, and polypeptide from glioblastoma; B) chaperone: 90 kDa heat shock protein; C) ion channel: chloride channel protein 3; and D) cytoskeleton: cytovillin2/ezrin and vimentin.
|
11146166 |
2000 |
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A total of 14 clones could be matched to known genes and were categorized into four groups: A) transcription factors: prothymosin, CA150, p78 serine/threonine kinase, IL-1beta-stimulating gene, glucocorticoid receptor, MLN64/CAB1, gastrin-binding protein, and polypeptide from glioblastoma; B) chaperone: 90 kDa heat shock protein; C) ion channel: chloride channel protein 3; and D) cytoskeleton: cytovillin2/ezrin and vimentin.
|
11146166 |
2000 |
Glioma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Suppression of chloride channel 3 expression facilitates sensitivity of human glioma U251 cells to cisplatin through concomitant inhibition of Akt and autophagy.
|
23408563 |
2013 |
Glioma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Transcripts for ClC-2 thru ClC-7 were detected in a human glioma cell line by PCR, whereas only ClC-2, ClC-3, and ClC-5 protein could be identified by Western blot.
|
12843258 |
2003 |
Glioma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest CLC-3 promotes the aggressiveness of glioma at least in part through nuclear factor-κB pathway, and might be a novel prognostic biomarker and therapeutic target for glioma.
|
28969029 |
2017 |
Glioma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Therefore, the present study explored the involvement of CLCN3 in cisplatin resistance in human glioma U251 cells.
|
29963152 |
2018 |
Glioma
|
0.340 |
AlteredExpression
|
disease |
LHGDN |
Transcripts for ClC-2 thru ClC-7 were detected in a human glioma cell line by PCR, whereas only ClC-2, ClC-3, and ClC-5 protein could be identified by Western blot.
|
12843258 |
2003 |
Glioma
|
0.340 |
Biomarker
|
disease |
BEFREE |
In the present study we provide several lines of evidence that glioma Cl- currents are primarily mediated by ClC-2 and ClC-3, two genes that belong to the ClC superfamily.
|
12843258 |
2003 |
Global developmental delay
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together with developmental retardation and higher mortality, the Clcn3-/- mice showed neurological manifestations such as blindness, motor coordination deficit, and spontaneous hyperlocomotion.
|
12059962 |
2002 |
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
This review will highlight the major findings and recent advances in the study of ClC-3 Cl(-) channels in the cardiovascular system and discuss their important roles in cardiac and vascular remodeling during hypertension, myocardial hypertrophy, ischemia/reperfusion, and heart failure.
|
21602838 |
2011 |
HER2-positive carcinoma of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our results demonstrate that intracellular Cl<sup>-</sup> regulation by ANO1/ClC-3 participates in HER2 transcription, mediating the PI3K/AKT/mTOR and/or STAT3 signaling pathway(s) in HER2-positive breast cancer cells, and support the potential of ANO1/ClC-3 blockers as therapeutic options for patients with resistance to anti-HER2 therapies.
|
29949674 |
2018 |
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
|
21364753 |
2011 |
Human papilloma virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging (<i>p </i>= 0.016), tumour size (<i>p </i>= 0.039), vascular invasion (<i>p </i>= 0.045), interstitial infiltration depth (<i>p </i>= 0.012), lymphatic metastasis (<i>p </i>= 0.036), and HPV infection (<i>p </i>= 0.022).
|
30636929 |
2019 |
Hyperalgesia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Cltx causes hyperalgesia and decreased expression of ClC-3 in OVX rats.
|
31787875 |
2019 |
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
This review will highlight the major findings and recent advances in the study of ClC-3 Cl(-) channels in the cardiovascular system and discuss their important roles in cardiac and vascular remodeling during hypertension, myocardial hypertrophy, ischemia/reperfusion, and heart failure.
|
21602838 |
2011 |
Hypertrophic Cardiomyopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also provide Clcn3 as a direct target of miR-1-3p which sheds light on the mechanism of HCM.
|
29885652 |
2018 |
Impaired cognition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expressions of CLC-3 and TGF- beta RII with cognitive impairment were observed in diabetic rats.
|
30468668 |
2019 |
Juvenile Neuronal Ceroid Lipofuscinosis
|
0.200 |
Biomarker
|
disease |
MGD |
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.
|
15504734 |
2005 |
Juvenile Neuronal Ceroid Lipofuscinosis
|
0.200 |
Biomarker
|
disease |
MGD |
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis.
|
12059962 |
2002 |