|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results indicate that transcripts encoding ornithine decarboxylase (ODC), ODC antizyme, adenosylmethionine decarboxylase, and spermidine/spermine N1-acetyltransferase (SSAT) were significantly higher, whereas clusterin (sulfated glycoprotein 2) mRNA was significantly lower in tumors compared with the benign tissue.
|
10646846 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo administration of clusterin ASO plus paclitaxel acted synergistically to increase apoptosis and significantly delay Caki-2 tumor growth, compared to mismatch control oligonucleotide plus paclitaxel.
|
11571636 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Northern analysis quantified changes in clusterin mRNA levels in human PC-3 cells and tumors.
|
11504787 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo administration of antisense clusterin oligodeoxynucleotide and Ad5CMV-p53 resulted in a significant inhibition of s.c. PC3 tumor growth as well as lymph node metastases from orthotopic PC3 tumors compared with administration of either agent alone.
|
15713890 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that TRPM2 activity is important for tumor growth and for cell viability and survival following doxorubicin treatment and that interference with TRPM2-L function may be a novel approach to reduce tumor growth through modulation of HIF-1/2α, mitochondrial function, and mitophagy.
|
25391657 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Pre-treatment of mice with the 2'MOE-modified clusterin AS-ODN was associated with a significantly improved tumor response to dacarbazine as compared with animals pretreated with a scrambled control oligonucleotide.
|
15955107 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High expression of secreted or cytoplasmic CLU may represent a pro-survival stimulus because it confers increased resistance to killing by anti-cancer drugs or enhances tumour cell survival in specific niches.
|
19903745 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The clinical investigation showed that CLU, MMP-9 and VEGF were positively correlated with the tumor-node -metastasis (TNM) classification.
|
26716898 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Using an orthotopic model of breast cancer, we have also determined the effects of over-expression of clusterin on tumor growth and metastatic progression.
|
20307318 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Clusterin was expressed in 62.5% of tumors within the tissue microarray.
|
16373699 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Within our microarray study in sinonasal adenocarcinoma we identified two proteins, LGALS4 and CLU, that were significantly differentially expressed in tumors compared to normal tissue.
|
19903339 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, after the orthotopic implantation of KoTCC-1 cells, combined treatment with AS clusterin and cisplatin significantly inhibited the growth of primary KoTCC-1 tumors, as well as the incidence of lymph node metastasis.
|
11751526 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Elevated levels of clusterin (CLU), a stress-induced and secreted cytoprotective chaperone, are associated with advanced tumor stage, metastasis, treatment resistance, and adverse outcome in several cancers.
|
24156019 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Attenuation is associated with increased expression of Hsp90, Hsp70, Hsp27, and clusterin (CLU) that mediate tumor cell survival and treatment resistance.
|
21737488 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings indicate that clusterin and bcl-2 are upregulated in laryngeal carcinomas and their expression is related to the invasiveness of these tumors.
|
16675913 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both clusterin silencing or VP treatment deterred tumor growth in human GCSC xenografts.
|
30745823 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our objective was to compare protein (HIF-1alpha, EPAS1, SDHB, JunB, CCND1, CD34, CLU) and gene (VEGF, BNIP3) expression patterns in VHL and SDHB/D associated tumors.
|
16954163 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, combined treatment of mice bearing androgen-independent recurrent Shionogi tumors with antisense TRPM-2 ODN and micellar paclitaxel inhibited tumor growth compared with treatment with either agent alone.
|
10811138 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
One gene, clusterin, not previously known to be expressed in lymphoid neoplasms, was specifically found in all 4 anaplastic large-cell lymphoma (ALCL) cell lines, but not in any of the 27 remaining tumor lines.
|
10887098 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A possible role for CLU as a novel tumor-suppressor gene in the prostate is thus suggested.
|
15358631 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Consistently, the aforementioned associations and the CLU mRNA expression levels are significantly enhanced as CRC tumors progress from TNM stage I to IV, further supporting the functional implication of CLU in tumorigenesis.
|
31672651 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review summarizes our present understanding of the importance of CLU in various physiological functions including tumour growth, and discusses its relevance to future cancer therapy.
|
16179938 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Clusterin shows possible important functions in tumor suppression by the VHL gene product (pVHL) and the potential to be a novel biomarker in retinal hemangioblastoma associated VHL disease.
|
18079682 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This has led us to focus on molecules associated with resistance, such as the molecular chaperones heat shock proteins (HSPs) and clusterin (CLU), and the cytokines interleukin-6 (IL-6) and the divergent member of the tumor growth factor family MIC-1 (macrophage inhibitory cytokine-1 also named GDF-15).
|
24969394 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that secretory clusterin plays a significant role in tumor growth and metastatic progression.
|
23099883 |
2012 |