CLU, clusterin, 1191

N. diseases: 412; N. variants: 14
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 AlteredExpression disease BEFREE Our data suggest that, in individuals with TDP-43 pathology, predominantly neuronal expression of clusterin in extra-motor brain regions may indicate a cell protective mechanism delaying clinical manifestations such as cognitive dysfunction. 31386770 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 Biomarker disease BEFREE These findings demonstrate that clusterin is necessarily involved in early stages of AD pathogenesis by enhancing toxic Aß pools to cause Aß-directed neurodegeneration and behavioral and cognitive impairments, but not in late stage. 30295351 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 GeneticVariation disease BEFREE In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients. 28631188 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 Biomarker disease CTD_human Analysis of cognitive performance and polymorphisms of SORL1, PVRL2, CR1, TOMM40, APOE, PICALM, GWAS_14q, CLU, and BIN1 in patients with mild cognitive impairment and cognitively healthy controls. 30503753 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 Biomarker disease BEFREE Plasma clusterin could serve as a biomarker for the severity of cognitive decline. 29169407 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 GeneticVariation disease BEFREE We examined the effect of the novel Alzheimer's disease (AD) risk variant rs11136000 single nucleotide polymorphism in the clusterin gene (CLU) on longitudinal changes in resting state regional cerebral blood flow (rCBF) during normal aging and investigated its influence on cognitive decline in presymptomatic stages of disease progression. 22795969 2013
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 GeneticVariation disease BEFREE In the present study CLU genotypes and haplotypes were associated with baseline cognition and the rate of cognitive decline in two cohorts, the Danish 1905 birth cohort (93 years of age in 1998) and the Longitudinal Study of Aging Danish twins (LSADT) (73-83 year old twins in 1997). 24244428 2013
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 Biomarker disease BEFREE CLU and CR1 were associated with more rapid cognitive decline. 22952074 2012
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.380 GeneticVariation disease BEFREE Both the PICALM and CLU variants showed nominal significant association with cognitive decline as measured by change in Clinical Dementia Rating-sum of boxes (CDR-SB) score from the baseline but did not pass multiple-test correction. 21390209 2011