SERPINA3, serpin family A member 3, 12

N. diseases: 229; N. variants: 8
Disease: Senile Plaques ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.050 Biomarker disease BEFREE The ACT gene, which is found on chromosome 14, has previously been proposed as a candidate for AD due to the presence of the ACT protein in senile plaques and the reported elevation of the protein in the cerebro-spinal fluid (CSF) and serum of AD cases. 9129722 1997
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.050 Biomarker disease BEFREE Alpha-1-Antichymotrypsin (ACT) is a serum glycoprotein frequently associated with vascular and senile plaque amyloid. 11132933 2000
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.050 Biomarker disease BEFREE Alpha1-antichymotrypsin (ACT: new identification SERPINA3) is a member of the serine proteinase inhibitor (serpin) gene family and biochemically has been shown to be a constituent of the senile plaques of Alzheimer's disease. 11702211 2001
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.050 Biomarker disease BEFREE alpha-1-Antichymotrypsin (ACT) is present in neuritic plaques in which it participates in the inflammatory cascade of Alzheimer's disease (AD). 12509851 2003
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.050 Biomarker disease BEFREE ACT is a major component of the senile plaques (SP) characteristic of Alzheimer's disease (AD). 15530656 2004