SERPINA3, serpin family A member 3, 12

N. diseases: 229; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.340 Biomarker disease BEFREE We aim to characterize the metabolic changes associated with early response to radiation therapy in a prostate cancer mouse model by 2-deoxy-2-[<sup>18</sup>F]fluoro-d-glucose ([<sup>18</sup>F]FDG) and [<sup>11</sup>C]acetate ([<sup>11</sup>C]ACT) positron emission tomography, with nuclear magnetic resonance (NMR) metabolomics corroboration. 29125557 2017
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.340 Biomarker disease CTD_human Allele and genotype frequencies of a promoter single nucleotide polymorphism (SNP) in ACT gene were investigated in patients with benign prostate hypertrophy (BHP) or PCa and controls. 18383875 2008
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.340 GeneticVariation disease BEFREE Allele and genotype frequencies of a promoter single nucleotide polymorphism (SNP) in ACT gene were investigated in patients with benign prostate hypertrophy (BHP) or PCa and controls. 18383875 2008
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.340 Biomarker disease BEFREE To evaluate the diagnostic utility of free PSA (fPSA) and complexed PSA forms for identification of men with PCa in the low PSA range of <4 microg/l, total PSA (tPSA), alpha(1)-antichymotrypsin complexed PSA (PSA-ACT) and fPSA (Roche Elecsys [ES] system) as well as tPSA and complexed PSA (cPSA) (Bayer Immuno 1 system) were measured in archival serum samples from 31 untreated patients with PCa, 66 patients with BPH, and 90 men without prostatic disease. 11477592 2001
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.340 AlteredExpression disease BEFREE Our objective was to investigate the presence of prostate specific antigen (PSA) and alpha-1-antichymotrypsin (ACT) mRNA and protein in prostate cancer cell lines, and the complexing characteristics of expressed PSA. 9568677 1998
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.330 Biomarker group BEFREE Clients with psychosis who need ACT may benefit from Flexible ACT through improved social functioning. 29373933 2018
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.330 Biomarker disease BEFREE Clients with psychosis who need ACT may benefit from Flexible ACT through improved social functioning. 29373933 2018
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.330 Biomarker group BEFREE In this first RCT of a psychological therapy with depression as the primary outcome, ACT is a promising intervention for depression in the context of psychosis. 27894822 2017
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.330 Biomarker disease BEFREE In this first RCT of a psychological therapy with depression as the primary outcome, ACT is a promising intervention for depression in the context of psychosis. 27894822 2017
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.330 GeneticVariation group BEFREE The objective of this study was to examine the effect of APOE4 and alpha1-antichymotrypsin/AA (ACT/AA) genotypes on time to psychosis onset in subjects with AD. 11936240 2002
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.330 GeneticVariation disease BEFREE The objective of this study was to examine the effect of APOE4 and alpha1-antichymotrypsin/AA (ACT/AA) genotypes on time to psychosis onset in subjects with AD. 11936240 2002
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.300 Biomarker group CTD_human Alpha 1 antichymotrypsin genotype is associated with increased risk of prostate carcinoma and PSA levels. 18383875 2008
CUI: C0023794
Disease: Lipoidosis
Lipoidosis
0.300 Biomarker disease CTD_human Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. 17175557 2007
CUI: C0023794
Disease: Lipoidosis
Lipoidosis
0.300 Biomarker disease CTD_human Improved toxicogenomic screening for drug-induced phospholipidosis using a multiplexed quantitative gene expression ArrayPlate assay. 16919414 2006
CUI: C0023794
Disease: Lipoidosis
Lipoidosis
0.300 Biomarker disease CTD_human A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. 15342952 2005
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.210 Biomarker disease BEFREE An in vitro assay revealed that the human homologue SERPINA3 increased the transendothelial permeability of retinal microvascular endothelial cells, which may be involved in the pathogenesis of diabetes and/or diabetic retinopathy. 23545169 2013
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.210 Biomarker disease CTD_mouse Anti-inflammatory and antioxidant effects of SERPINA3K in the retina. 19324842 2009
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.200 Biomarker disease CTD_mouse Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0021368
Disease: Inflammation
Inflammation
0.200 Therapeutic phenotype CTD_mouse Anti-inflammatory and antioxidant effects of SERPINA3K in the retina. 19324842 2009
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases
0.200 Therapeutic group CTD_mouse Anti-inflammatory and antioxidant effects of SERPINA3K in the retina. 19324842 2009
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.200 Biomarker disease CTD_mouse Identification of fibrosis-relevant proteins using DIGE (difference in gel electrophoresis) in different models of hepatic fibrosis. 15650968 2005
CUI: C1862939
Disease: AMYOTROPHIC LATERAL SCLEROSIS 1
AMYOTROPHIC LATERAL SCLEROSIS 1
0.200 Biomarker disease CTD_mouse Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. 11796754 2002
Amyotrophic Lateral Sclerosis, Sporadic
0.200 Biomarker disease CTD_mouse Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. 11796754 2002
Amyotrophic Lateral Sclerosis, Familial
0.200 Biomarker disease CTD_mouse Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. 11796754 2002
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker disease BEFREE Participants had adequately controlled asthma (mean ACT or cACT score = 21.6 ± 2.8) at baseline. 31371165 2020