SERPINA3, serpin family A member 3, 12

N. diseases: 229; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0497327
Disease: Dementia
Dementia
0.070 AlteredExpression disease BEFREE C-reactive protein (HR = 1.37 [1.05; 1.78]), interleukin-6 (HR = 1.40 [1.13; 1.73]), α1-antichymotrypsin (HR = 1.54 [1.14; 2.80]), lipoprotein-associated phospholipase A2 activity (HR = 1.40 [1.03; 1.90]), and fibrinogen were each associated with all-cause dementia, but neither was significantly associated with AD. 29605221 2018
CUI: C0497327
Disease: Dementia
Dementia
0.070 AlteredExpression disease BEFREE ACT has been shown to promote Abeta polymerization in vitro and in vivo, and levels of ACT protein in plasma and cerebrospinal fluid from Alzheimer's patients have been found to correlate with progression of dementia. 16987932 2006
CUI: C0497327
Disease: Dementia
Dementia
0.070 GeneticVariation disease LHGDN Post-stroke dementia is associated with alpha(1)-antichymotrypsin polymorphism. 15935385 2005
CUI: C0497327
Disease: Dementia
Dementia
0.070 GeneticVariation disease BEFREE Apolipoprotein E, angiotensin-converting enzyme and alpha-1-antichymotrypsin genotypes are not associated with post-stroke dementia. 12736093 2003
CUI: C0497327
Disease: Dementia
Dementia
0.070 AlteredExpression disease BEFREE We found that plasma ACT levels were elevated in AD patients compared with the control group (p = 0.01) and were associated with severity of AD dementia; there was a negative association with the Mattis Dementia Rating Scale (a global measure of cognition) and a positive association with the Clinical Dementia Rating Scale (a global functional assessment). 12509851 2003
CUI: C0497327
Disease: Dementia
Dementia
0.070 GeneticVariation disease BEFREE We conclude that unlike the general population, neither PS-1 nor ACT polymorphisms appear to have a similar detrimental effect on dementia in DS.Am.J. Med.Genet.(Neuropsychiatr.Genet.)88:616-620, 1999. 10581479 1999
CUI: C0497327
Disease: Dementia
Dementia
0.070 GeneticVariation disease BEFREE Absence of the A1252G mutation in alpha 1-antichymotrypsin in a North American population suffering from dementia. 9040504 1997