Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variants in the leucine-rich repeat kinase-2 (<i>LRRK2</i>) gene are associated with Parkinson's disease, leprosy, and Crohn's disease, three disorders with inflammation as an important component.
|
31554740 |
2019 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
LRRK2, the gene encoding the multidomain kinase Leucine-Rich Repeat Kinase 2 (LRRK2), has been linked to familial and sporadic forms of Parkinson's disease (PD), as well as cancer, leprosy and Crohn's disease, establishing it as a target for discovery therapeutics.
|
30055128 |
2018 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leucine-rich repeat kinase 2 (<i>LRRK2</i>) has been associated with a variety of human diseases, including Parkinson's disease and Crohn's disease, whereas <i>LRRK2</i> deficiency leads to accumulation of abnormal lysosomes in aged animals.
|
30209220 |
2018 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We show that dendritic cells (DCs) from patients with Crohn's disease (CD) and lymphoblastoid cell lines derived from patients without CD but bearing a high-risk allele (rs11564258) at this locus as heterozygotes exhibited increased LRRK2 expression in vitro.
|
29875204 |
2018 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We specifically attempt to evaluate whether strong acting rare alleles, particularly protein-truncating or otherwise large effect-size alleles, enriched by the same founder-effect, contribute excess genetic risk to Crohn's disease in AJ, and find that ten rare genetic risk factors in NOD2 and LRRK2 are enriched in AJ (p < 0.005), including several novel contributing alleles, show evidence of association to CD.
|
29795570 |
2018 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively investigated the co-occurrence of Crohn's disease in a cohort of 876 patients with Parkinson's disease, based on the observation that LRRK2 is a shared genetic risk factor.
|
28215729 |
2017 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we found that LRRK2, encoded by a gene implicated in Crohn's disease, leprosy and familial Parkinson's disease, modulates the strength of Nod1/2-Rip2 signaling by enhancing Rip2 phosphorylation.
|
27830463 |
2017 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
While genome-wide association studies (GWAS) has linked LRRK2 with Crohn's disease and leprosy, it has received the greatest attention due to it being implicated as one of the genetic loci associated with autosomal dominant inheritance in Parkinson's disease (PD).
|
28117607 |
2017 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leucine rich repeat kinase 2 is a complex enzyme with both kinase and GTPase activities, closely linked to the pathogenesis of several human disorders including Parkinson's disease, Crohn's disease, leprosy and cancer.
|
27731364 |
2016 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the gene encoding LRRK2 have been linked to multiple diseases, including a prominent association with familial and sporadic Parkinson's disease (PD), as well as inflammatory bowel disorders such as Crohn's disease.
|
23729298 |
2014 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy.
|
23967090 |
2013 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We studied associations between nonsynonymous coding variants in the MUC19 (5) and LRRK2 (3) genes in a case-control sample comprising CD cases aged <18 years at diagnosis.
|
23619718 |
2013 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have identified several genes implicated in autophagy (ATG16L1, IRGM, ULK1, LRRK2, and MTMR3), intracellular bacterial sensing (NOD2), and endoplasmic reticulum (ER) stress (XBP1 and ORMDL3) to be associated with Crohn disease (CD).
|
24247223 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD patients, 626 controls) and assessed for association with CD clinical characteristics.
|
22573572 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's disease and leprosy.
|
22302802 |
2012 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Additionally, in genome-wide association studies, the LRRK2 locus has been linked to risk of PD, Crohn's disease and leprosy, and LRRK2 has also been linked with cancer.
|
22988880 |
2012 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson's disease; Crohn's disease; and leprosy.
|
22594666 |
2012 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, the risk-associated allele encoding LRRK2 Met2397 identified by a genome-wide association study for Crohn's disease resulted in less LRRK2 protein post-translationally.
|
21983832 |
2011 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A pattern recognition receptor-type function for LRRK2 could explain its locus' association with Crohn's disease and leprosy risk.
|
21552986 |
2011 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |