TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease BEFREE Further investigations of Tph2 are needed to clarify the potential role of this gene in the pathophysiology of bipolar disorder. 16240163 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE TPH2 genotypes were determined in 69 subjects with a diagnosis of schizophrenia or bipolar disorder, among which 22 died by suicide. 16436194 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample. 16806105 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease BEFREE Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. 17015812 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease LHGDN Case-control and family-based association studies further support the presence of a susceptibility locus for bipolar disorder in tryptophan hydroxylase 2 by showing statistically significant associations with both, single nucleotide polymorphism alone and haplotype of single nucleotide polymorphism markers. 17167340 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Case-control and family-based association studies further support the presence of a susceptibility locus for bipolar disorder in tryptophan hydroxylase 2 by showing statistically significant associations with both, single nucleotide polymorphism alone and haplotype of single nucleotide polymorphism markers. 17167340 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Despite reports of possible associations between polymorphisms in human TPH2 and many psychiatric disorders, including bipolar disorder (BPD), the functional effect and susceptibility loci of such polymorphisms for BPD have not yet been identified. 17768266 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease LHGDN Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD. 17905754 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD. 17905754 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease BEFREE These results strongly support a role for TPH2 in the aetiology of BPAD. 19352219 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Our findings do not support the association between diagnosis of BD or suicidal behavior and TPH2 polymorphisms. 19800079 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET The aim of this study is to investigate a possible association between TPH2 gene polymorphisms and the PD comorbidity susceptibility.Our sample consisted of 515 patients; 274 patients with BD (subtypes I and II), including 45 patients with lifetime panic disorder comorbidity and 241 controls. 21085052 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE The aim of this study is to investigate a possible association between TPH2 gene polymorphisms and the PD comorbidity susceptibility.Our sample consisted of 515 patients; 274 patients with BD (subtypes I and II), including 45 patients with lifetime panic disorder comorbidity and 241 controls. 21085052 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments. 21396719 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within the tryptophan hydroxylase 2 gene (TPH2) could be associated with major depression (MD), bipolar disorder (BD) and schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antidepressants, mood stabilizers and antipsychotics, respectively. 21396719 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post-hoc analyses, specifically against bipolar disorder or major depressive disorder. 21438144 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease BEFREE Our results indicate that in the Han Chinese population TPH2 may be a potential susceptibility gene for bipolar disorder. 25152196 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET Our results indicate that in the Han Chinese population TPH2 may be a potential susceptibility gene for bipolar disorder. 25152196 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Eight eligible studies addressed association between 63 TPH2 gene single nucleotide polymorphisms (SNPs) with BD, after linkage disequilibrium analysis, 12 independent SNPs were identified. 26365518 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease BEFREE These findings delineate 5-HT as a critical determinant in BD associated maladaptive emotional responses and aberrant hippocampal neuroplasticity, and support the use of Tph2-/- mice as a new research tool for mechanistic and therapeutic research in bipolar disorder. 30087403 2018