Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system.
|
15124006 |
2004 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.
|
15629698 |
2005 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide.
|
16192985 |
2006 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent.
|
16806105 |
2007 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene and its 5' upstream region may predispose to suicide in major depressive disorder (MDD) and whether this predisposition is mediated by impulsive-aggressive behaviors (IABs).
|
17217922 |
2007 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in the TPH2 gene have been associated with an increased risk for major depression and suicidal behavior.
|
17251907 |
2007 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1.
|
17692928 |
2008 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This SNP and additional SNPs were discovered through a systematic characterization of the genetic architecture of the TPH2 gene for further genetic and functional investigations of its relationship to major depression and other psychopathology.
|
18180764 |
2008 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The mechanisms underlying these changes are uncertain, but increased TPH2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression.
|
19120094 |
2008 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, an increased frequency of G allele of TPH2 SNP may be associated with elevated suicidal behavior itself rather than with the diagnosis of major depression and may increase risk of suicidality, independent of diagnosis.
|
19162119 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings show that TPH2 genetic variants may play a role in MDD susceptibility and in acute therapeutic response to selective serotonin reuptake inhibitors.
|
19272410 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the sample size is small, results from this study suggest that the TPH2 C2755A polymorphism may represent a population-specific risk factor for peripartum major depression and anxiety disorder, perhaps by interacting with hormones.
|
19588223 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Those who did not drink alcohol before suicide were more likely to have a diagnosis of major depressive disorder in their medical record and more often had the TT genotype of the tryptophan hydroxylase 2 gene.
|
19734157 |
2010 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The study suggested that hopelessness, negative life events and family history of suicide were risk factors of attempted suicide in MDD while the TPH2 rs7305115A remained a significant protective predictor of suicide attempts.
|
20738857 |
2010 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments.
|
21396719 |
2011 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to investigate the association of tryptophan hydroxylase 2 gene with MDD and its treatment response in the Chinese Han population.
|
21620479 |
2011 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder.
|
21937687 |
2012 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced contradictory results.
|
22693556 |
2012 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels.
|
23336047 |
2013 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD.
|
24196946 |
2014 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Single locus analysis in pooled and ethnically stratified subjects revealed no association between each of the three variants of the TPH2 gene with susceptibility to MDD.
|
24376086 |
2015 |