|
Anxiety Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Priming with Ucn1 increased tph2 mRNA expression selectively within the anxiety-related dorsal part of the DR (DRD) and decreased social interaction (SI) time, a measure of anxiety-related defensive behavioral responses in rodents.
|
31415826 |
2020 |
|
Anxiety Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the full cohort of mice, TPH2 activity in the mid-rostrocaudal DR was correlated with anxious behaviour in the EPM, however these correlations were not statistically significant within each strain, suggesting that TPH2 activity was not directly associated with either anxiety or sociability.
|
29935278 |
2019 |
|
Anxiety Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We conclude that BH<sub>4</sub> treatment of HPA toward systemic L-Phe lowering reverses elevated brain L-Phe content but the recovery of TPH2 protein and activity as well as serotonin levels is suboptimal, indicating that patients with mild HPA and mood problems (depression or anxiety) treated with the current diet may benefit from supplementation with BH<sub>4</sub> and 5-OH-tryptophan.
|
29520738 |
2018 |
|
Anxiety Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
TPH2 genetic variability may be also associated with anxiety and aggression traits in alcohol dependent subjects.
|
26232682 |
2015 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to citalopram among children and adolescents with depression and anxiety disorders.
|
23510446 |
2013 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Specifically, the correlation between amygdala-hippocampus connectivity and Gray's trait anxiety scores is positive in individuals homozygous for the TPH2 G-allele, while carriers of at least one T-allele show a negative association.
|
23684859 |
2013 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The findings suggest that these polymorphisms in TPH2 gene are involved in development of poststroke anxiety in the Han Chinese population.
|
22835848 |
2013 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The haplotype structure of TPH2 was defined for 16 single-nucleotide polymorphisms (SNPs) in a healthy subject population and a haplotype block analysis confirmed the presence of a six SNP haplotype in a yin configuration that has previously been associated with risk for suicidality, depression, and anxiety disorders.
|
22915309 |
2012 |
|
Anxiety Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on genetic variation, there is accumulating evidence that altered function of tryptophan hydroxylase-2 (TPH2), the enzyme critical for synthesis of serotonin (5-HT) in the brain, plays a role in anxiety-, aggression- and depression-related personality traits and in the pathogenesis of disorders featuring deficits in cognitive control and emotion regulation.
|
21257271 |
2011 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic variations in human TPH2, a newly identified isoform of TPH, have been shown to impact on enzymatic activity of TPH and to be associated with emotion-related personality traits and mood/anxiety disorders.
|
20331984 |
2010 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although the sample size is small, results from this study suggest that the TPH2 C2755A polymorphism may represent a population-specific risk factor for peripartum major depression and anxiety disorder, perhaps by interacting with hormones.
|
19588223 |
2009 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We did not observe a role for TPH2 variants in the efficacy of treatment in relieving anxiety and other psychopathological symptoms.
|
19361870 |
2009 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A gene x glycemic control interaction (p=0.032) was observed on the anxiety scale at the TPH2 promoter polymorphism: the -703T-allele decreased anxiety scores only in the GC group (p=0.008).
|
18801407 |
2008 |