TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior
0.040 GeneticVariation phenotype BEFREE Genetic variants in TPH1 (rs591556) were associated with sensation seeking and impulsivity, while genetic variants in TPH2 (rs17110451) were associated with the fraction of drinkers in family. 29697747 2019
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior
0.040 GeneticVariation phenotype BEFREE We examined whether the TPH2 polymorphism -703G/T (rs4570625) is associated with aggressiveness and impulsivity, and the prevalence of psychiatric disorders, in a population-representative sample. 28342337 2017
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior
0.040 GeneticVariation phenotype BEFREE Genetic influence was examined via interaction analyses between the TPH2 genotype (GG homozygotes vs T allele carriers) and the degree of impulsivity as measured by the 5-CSRTT. 27824354 2016
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior
0.040 GeneticVariation phenotype BEFREE Genetic variation at the TPH2 gene appeared to affect impulsivity which, in turn, might predispose to the SV phenotype. 23239044 2013