TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Anxiety symptoms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0860603
Disease: Anxiety symptoms
Anxiety symptoms 		0.040 GeneticVariation phenotype BEFREE TPH2 rs4570625 GG carriers were more likely to achieve depressive and anxiety symptom remission compared with T-allele carriers. 26745768 2016
CUI: C0860603
Disease: Anxiety symptoms
Anxiety symptoms 		0.040 GeneticVariation phenotype BEFREE The effect of TPH2 haplotypes on risk-taking was independent of current depression and anxiety symptoms, neuroticism and impulsiveness scores. 20043001 2010
CUI: C0860603
Disease: Anxiety symptoms
Anxiety symptoms 		0.040 GeneticVariation phenotype BEFREE TPH2 variants have been consistently associated with anxiety-related traits; since anxiety is critical for alcohol dependence treatment, in the present paper we investigated 9 SNPs within the THP2 gene in anxiety symptoms during the detoxification procedure. 19361870 2009
CUI: C0860603
Disease: Anxiety symptoms
Anxiety symptoms 		0.040 GeneticVariation phenotype BEFREE Moreover, the TPH2 polymorphism was a significant predictor of clinical placebo response, homozygosity for the G allele being associated with greater improvement in anxiety symptoms. 19052197 2008