CMA1, chymase 1, 1215

N. diseases: 157; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 Biomarker disease BEFREE MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the LKB1/AMPK signaling. 31409796 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 AlteredExpression disease BEFREE Immunohistochemistry of human CRC tissues revealed reciprocal expression of MCT1 and MCT4 in carcinoma and stroma cells, respectively, accompanied by strong epithelial Nrf2 activation. 28846107 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 AlteredExpression disease BEFREE CRC cell exposure to acetate upregulates the expression of MCT1, MCT4 and CD147, while promoting MCT1 plasma membrane localization. 28874966 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 GeneticVariation disease BEFREE Two other SNPs (MCT1: rs60844753/5' near gene and MCT2: rs995343/intron) exhibited associations with recurrence-free survival of CRC patients (HR 0.67; P = 0.078 and HR 0.74; P = 0.036, respectively). 25492048 2015