|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
We cloned HIV-1 envelopes from virus at acute infection and found that most use CCR3 efficiently.
|
16712896 |
2006 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CCR3, receptor of CCL28, was highly expressed in vascular endothelial cells in lung adenocarcinoma when examining by immunohistochemistry.
|
27250766 |
2016 |
|
Adult Anaplastic Large Cell Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CCR3 was expressed in 73% of cases of CD30+ lymphoproliferative disorders such as lymphomatoid papulosis and anaplastic large cell lymphoma.
|
31045236 |
2019 |
|
Adult Anaplastic Large Cell Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CCL11-CCR3 interactions promote survival of anaplastic large cell lymphoma cells via ERK1/2 activation.
|
21406396 |
2011 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression and prognostic significance of CCL11/CCR3 in glioblastoma.
|
27119233 |
2016 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Herein we describe the effects of morphine and/or gp120 on the expression of the genes for the beta-chemokine MIP-1beta and its receptors CCR3 and CCR5 by the U373 cells which are a human brain-derived astrocytoma/glioblastoma cell line.
|
16022659 |
2005 |
|
Adult Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The eotaxin receptor CCR3 was expressed in both stromal and carcinoma cell populations of HL-like UCNT, this pattern being similar to the one observed in HL.
|
12792781 |
2003 |
|
Age related macular degeneration
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings suggest that inhibition of retinal CCR3 causes retinal cell death and that targeted inhibition of CCR3 in CECs may be a safer if CCR3 inhibition is considered as a therapy for neovascular AMD.
|
27309355 |
2016 |
|
Age related macular degeneration
|
0.030 |
Biomarker
|
disease |
BEFREE |
CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition.
|
19525930 |
2009 |
|
Age related macular degeneration
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The genotype distribution of CCR3 (rs3091250) polymorphism was significantly different in AMD patients in the Indian population.
|
23566847 |
2013 |
|
airway disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
This CCL26-CCR3 ligand-receptor system may be an attractive target for development of therapeutics that limits progress of inflammation in airway disease.
|
15863444 |
2005 |
|
airway disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Eotaxin-1/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26 bind specifically and exclusively to CC chemokine receptor (CCR) 3, which is a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases.
|
14698143 |
2003 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to enumerate CD34(+) cell numbers in blood and bone marrow from atopic asthmatics and control subjects and to test the hypothesis that there is an increased bone marrow pool of CCR3(+) eosinophils in patients with atopic asthma, as compared with control subjects.
|
9893192 |
1999 |
|
Allergic rhinitis (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
The present study aimed to use RNA interference (RNAi) to silence chemokine receptor 3 (CCR3) and observe the effects on eosinophils (EOS) in mice with allergic rhinitis (AR).
|
28123492 |
2017 |
|
Allergic rhinitis (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
Compared with the CG‑associated groups (i.e., the CG and CCR3‑/‑CG groups), the levels of EPO, ECP, MBP, IL‑4, and IgE were significantly increased in the AR‑associated groups (that is, R and CCR3‑/‑AR).
|
30106146 |
2018 |
|
Allergic rhinitis (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to explore whether silencing of CCR3 with short hairpin RNAs (shRNAs) delivered by a lentiviral vector could impact the function of mast cells in a murine model of allergic rhinitis (AR) in vivo.
|
31776094 |
2020 |
|
Alveolitis, Fibrosing
|
0.300 |
Biomarker
|
disease |
CTD_human |
Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis.
|
16314464 |
2005 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, the age-related increase in CCL11 may be a risk factor of AD, and antagonizing CCR3 may bring therapeutic benefits to AD.
|
27878757 |
2017 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results support CCR3 antagonism as a potential therapeutic strategy for AD.
|
31121157 |
2019 |
|
Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation.
|
11056090 |
2000 |
|
Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The chemokine receptors CCR3 and CXCR4 are present and functional on SMC and are up-regulated in vascular diseases such as atherosclerosis.
|
16343467 |
2006 |
|
Aspirin exacerbated respiratory disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This result suggests that the CCR3 genetic polymorphisms may contribute to the development of the AERD phenotype and may be used as a genetic marker for differentiating between the two major aspirin hypersensitivity phenotypes.
|
20022477 |
2010 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
RGD |
Topical inhibition of CCR3 expression, using an AS-ODN, could represent a novel approach for the treatment of asthma.
|
16978084 |
2006 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we decided to analyze the regulation of CCR3 by IFN-gamma in asthmatics and to characterize the dependence of this process on immunoglobulin E (IgE) levels.
|
18849613 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epithelial immunostaining for CCR3 was stronger in bronchial biopsies of asthmatics displaying marked inflammatory changes than in nondiseased samples.
|
16920975 |
2006 |