CCR7, C-C motif chemokine receptor 7, 1236

N. diseases: 320; N. variants: 3
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 GeneticVariation disease BEFREE In this paper, we have analyzed chromosomal rearrangements in two leukemia cell lines derived from CML-BC with inv(3)(q21q26) and have identified the breakpoints within the EVI1 coding area. 9192861 1997
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE The PTEN/AKT/mTOR signaling pathway and the Evi1-polycomb interaction can be promising therapeutic targets for leukemia with activated Evi1. 21289308 2011
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE As EVI1 overexpression alone is not sufficient to induce leukemia, loss of a 7q tumour suppressor gene might be a required cooperating event. 20084277 2010
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Histone deacetyltransferase could be a target in molecular therapy of RUNX1-EVI1-expressing leukemia. 19016745 2008
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Genetic deletion of CXCR4 in murine hematopoietic progenitors abrogated leukemogenesis induced by constitutively active Notch1, whereas lack of CCR6 and CCR7, which have been shown to be involved in T cell and leukemia extravasation into the central nervous system, respectively, did not influence T cell acute lymphoblastic leukemia development. 26931577 2016
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE These findings provide a foundation for future study of potential therapeutic gene targets for EVI1-induced leukemia. 23826213 2013
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Evi-1 is a transforming gene originally identified in a common integration site of murine leukemia retrovirus and mapped in human chromosome 3q26. 8656673 1996
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 GeneticVariation disease BEFREE Although it is unlikely that the Rb gene is directly involved in this translocation, the loss of the Rb gene product combined with the activation of the EVI1 gene may have led to the development of leukemia. 8813093 1996
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE We propose that rearrangements at 3q26 involving EVI1 could result in leukemia by a two-step process involving first transcriptional disruption of MDS1/EVI1, and next by inappropriately activating expression of EVI1. 9067573 1997
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE These results suggest that EVI1 overexpression was the major factor contributing to leukemogenesis, and the late appearance of the Ph chromosome is closely associated with the progression to an aggressive form of leukemia. 18206536 2008
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE These results establish the mechanistic basis underlying the pathogenesis of a severe form of leukemia through aberrant expression of the EVI1 proto-oncogene. 24703906 2014
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Overexpression of EVI-1 also occurs with high frequency in leukemia patients without 3q26 abnormalities, and importantly, high EVI-1 expression is an independent negative prognostic indicator irrespective of the presence of 3q26 rearrangements. 19385966 2009
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Our results suggest that the leukemogenic role of EVI1 expression may differ between post-MDS AML and leukemia, with EVI1 expression associated with a 3q26 abnormality. 7780155 1995
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Steady-state evi-1 transcripts were detected in UCSD/AML1 and murine leukemia M1 cells, but were not present in HL60 or Namalwa human leukemia cells. 1593910 1992
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. 24703711 2014
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE These data indicate that expression of the EVI1 gene is involved in progression of megakaryocytic differentiation and, thus, the dysmegakaryocytopoiesis in 3q21q26 syndrome could be partly due to an enhanced differentiation capacity of leukemia cells and/or megakaryocytes by constitutive expression of the EVI1 gene. 11922610 2002
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE High EVI1 expression was detected mainly in myelomonocytic-lineage (designated as e-M4/M5 subtype) leukemia with MLL rearrangements and in megakaryocytic-lineage (designated as e-M7 subtype) leukemia, and its prognostic association was observed in the e-M4/M5 subtype but not in the e-M7 subtype. 25567132 2015
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Using the Evi1(pos) MLL-AF9 mouse leukemia model, we demonstrate increased sensitivity to chemotherapeutic agents on reduction of Evi1 expression. 22553314 2012
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Experimental overexpression of EVI1 by itself was insufficient to cause leukemia in animal model systems, but it cooperated with other genes in this process. 17507183 2007
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Specific gene activation (N-myc, evi-1) or fusion genes such as the alpha retinoic acid receptor (alpha RAR) and pml have been identified as the specific cause of some cases of leukemia. 1434816 1992
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE EVI-1 (ecotropic virus integration site-1) was at first identified as an integration site of the murine leukemia retrovirus in murine myeloid leukemias. 10867128 2000
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE EVI1 expression associated with a 3q26 anomaly in a leukemia cell line derived from the blast crisis of chronic myeloid leukemia. 7808006 1994
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Leukemia fusion gene analysis demonstrated positive EVI1 and negative IgH and TCR gene rearrangement. 30608452 2019
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE To further define potential roles for EVI-1 in leukemia pathogenesis, we studied its regulation in acute promyelocytic leukemias (APL). 9009083 1997
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE The functions of EVI1/MEL1 members as transcription factors and the concept of EVI1-positive leukemia as a stem cell disease are also reviewed. 17483069 2007