CCR7, C-C motif chemokine receptor 7, 1236

N. diseases: 320; N. variants: 3
Disease: Secondary malignant neoplasm of lymph node ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.100 AlteredExpression disease BEFREE In human breast carcinomas, mRNA expression of endothelins correlated with the level of CCR7 expression, both of which were associated with the presence of lymph node metastases. 17178876 2006
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.100 AlteredExpression disease BEFREE Taken together, our results demonstrate that CCR7 activation on thyroid carcinoma cells by CCL21 - a chemokine abundantly expressed in lymph nodes - favours tissue invasion and cell proliferation, and therefore may promote thyroid carcinoma growth and LNM. 17065406 2006
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.100 Biomarker disease BEFREE However, in contrast to previous studies, the expressions of CCR7 or CXCR4 were not associated with lymph node metastasis. 15867478 2005
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.100 Biomarker disease BEFREE Our study demonstrates that CCR7 might be related to the development of lymph node metastasis in NSCLC. 12673677 2003
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.100 Biomarker disease BEFREE These results indicated that CCR7 and its ligands interaction is associated with preferential lymph node metastasis of gastric carcinoma. 12019175 2002