Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
ADH1B*1/*1 increased the risk of esophageal cancer among never/rare [1.56 (0.93-2.61)], moderate [2.71 (1.37-5.35)], and heavy drinkers [3.22 (2.27-4.57)].
|
20806441 |
2010 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis shows that the GG genotype of ADH2 G48A may be associated with an increased risk of EC in Asian populations.
|
24446180 |
2014 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The ADH2(1)/ADH2(1) and ALDH2(1)/ALDH2(2) genotypes were independently and significantly higher in esophageal cancer patients than in healthy controls.
|
9451664 |
1997 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Compared to Zoroastrians, Turkomans had higher frequency of four alleles that are speculated to favor carcinogenesis (CYP1A1 m1, CYP1A1 m2, CYP2A6*9, and ADH2*1); these results are consistent with an influence of these allele variants on the population risk of EC.
|
15327835 |
2004 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Literature studies discussed suggest an additional role of the acetaldehyde burst on the paradoxical (hormesis) protection of the ADH1B*2 polymorphism against esophageal cancers in alcoholics.
|
21284671 |
2011 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Both ADH2 G allele and ALDH2 A allele significantly increase the risk of esophageal cancer development in Southeast Chinese males.
|
19452585 |
2009 |
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
For individuals with both ALDH2*1/2*2 and ADH2*1/2*1, the risk of esophageal cancer was enhanced in a multiplicative fashion (OR = 30.12), whereas for those with either ALDH2*1/2*2 or ADH2*1/2*1 alone the ORs were 7.36 and 4.11.
|
12419833 |
2002 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADH2 and ALDH2 genotypes are associated with esophageal cancer risk.
|
17963305 |
2007 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, statistical interaction between ALDH2 and ADH1B polymorphisms on EC susceptibility among never/light drinkers was indicated.
|
22930414 |
2013 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
|
19698717 |
2009 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Compared with individuals carrying both ALDH2 G/G and ADH2 A/A alleles and with a cumulative amount of alcohol consumption <2.5 (kg * years), drinkers carrying both ALDH2 A and ADH2 G alleles and with a cumulative amount of alcohol consumption > or =2.5 (kg * years) showed a significantly elevated risk of esophageal cancer (OR=53.15, 95% CI: 4.24-666.84).
|
20010786 |
2010 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Inactive ALDH2 encoded by ALDH2*1/2*2 and the low-activity form of alcohol dehydrogenase (ADH)-2 encoded by ADH2*1/2*1 enhance the risk for esophageal cancer in Japanese light to heavy drinkers, a significant association that emphasizes the importance of screening tests for inactive ALDH2 based on alcohol flushing.
|
14652286 |
2003 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It was observed that ADH variants, ADH2*1 and ADH3*2, were associated with increased risk for oesophageal cancer, possibly due to the tolerance of the carriers of these alleles to alcohol consumption compared to those with high activity alleles (ADH2*2 and ADH2*3) which are associated with higher production of the unpleasant acetaldehyde intermediate.
|
18254707 |
2008 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for age, drinking and smoking habits, BMI and ALDH2/ADH2 genotypes, macrocytosis of MCV > or =106 fl was associated with increased risk for esophageal cancer (OR = 2.75).
|
12949054 |
2003 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that polymorphisms of ADH2 and ALDH2 can modify the influence of alcoholic consumption on esophageal cancer risk.
|
16127737 |
2005 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association of lifestyle habits and polymorphism of ADH2 and ALDH2 genes with the risk of esophageal cancer in Thai population was investigated in a hospital-based case-control study: 202 cases and 261 controls.
|
12213289 |
2002 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A review of case-control studies of the effects of ALDH2, ADH2 and ADH3 genotypes shows consistently positive associations between inactive heterozygous ALDH2 and the less-active ADH2 genotypes and the risk for esophageal cancer in East Asian heavy drinkers and this enzyme-related vulnerability may extend to light-to-moderate drinkers.
|
12672787 |
2003 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The key findings of the earlier studies were that variations (i.e., polymorphisms) in the DNA sequences of the genes encoding alcohol dehydrogenase 1B (i.e., the ADH1B gene), aldehyde dehydrogenase 2 (i.e., the ALDH2 gene), and other alcohol-metabolizing enzymes mediate the risk for alcoholism; moreover, these polymorphisms also have an impact on the risk of alcohol-related cancers, such as esophageal cancer.
|
23134043 |
2012 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADH1B rs1229984 polymorphism HRs for HNC and oesophageal cancer death and for alcohol related cancer death were 0.67 (95% CI: 0.42-1.08), and 0.64 (95% CI: 0.40-1.03), respectively.
|
25770642 |
2015 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, Arg/Arg genotype of ADH1B Arg47His variant combined with drinking, smoking and males appeared to show a high risk in patients with esophageal cancer.
|
27450204 |
2016 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also found a modifying effect of lifetime alcoholic consumption on the association between genotypes of ADH1B and ALDH2 on esophageal cancer risk.
|
17036331 |
2006 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Associations between ADH1B genotypes and the risk of esophageal cancer were estimated by computing the odds ratios (ORs) and their 95% confidence intervals (CIs) using logistic regression analyses for crude ORs and adjusted ORs when adjusting for age, gender, and tobacco use status.
|
24093763 |
2014 |
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2(*)1/(*)2) and less-active alcohol dehydrogenase-1B (ADH1B(*)1/(*)1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2(*)1/(*)2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus.
|
21601984 |
2011 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.
|
21157980 |
2010 |
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Alcoholics' population attributable risks due to ADH2/ALDH2 polymorphisms were estimated to be 82.0% for oropharyngolaryngeal cancer and 63.9% for esophageal cancer.
|
11238183 |
2001 |