Disease: Alcohol Use Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease BEFREE Findings support medium to large and unique associations of ALDH2, ADH1B, and ADH1C with AUD in East Asians. 30834931 2019
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease BEFREE ADH1B and ALDH2), few other candidate loci have been confidently linked to AUD. 29316088 2019
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE With longitudinal EHR data from the Million Veteran Program (MVP) linked to genetic data, we used two population-specific polymorphisms in ADH1B that are associated strongly with AUD in African Americans (AAs) and European Americans (EAs): rs2066702 (Arg369Cys, AAs) and rs1229984 (rs1229984" genes_norm="125">Arg48His, EAs) as criterion measures. 29972609 2018
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE Specifically, the ADH1B*3 allele is present almost exclusively in Black populations and has been protective against alcohol use and alcohol use disorder. 28662358 2018
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease BEFREE However, the suppressive effects of inactive ALDH2 and highly active ADH1B for AUDs are only partial and interact with other factors, such as personality traits, psychiatric comorbidities, and environmental factors. 28098394 2017
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease BEFREE Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence? 25828809 2016
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE Therefore, among those at risk for greater consumption, e.g. those who experienced childhood adversity, ADH1B-rs1229984 appears to have a stronger effect on alcohol consumption and consequently on risk for AUD symptom severity. 24164917 2015
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE ADH1B rs1229984 was significantly associated with AUDs and six criteria, with odds ratios ranging from 1.32 to 1.96. 24988262 2014
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been associated at a genome-wide level with alcohol use disorders in diverse adult populations. 25257461 2014
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE This study examined the joint effects of variation in ADH1B and childhood adversity-a well-documented risk factor for alcohol problems and moderator of genetic liability to psychiatric outcomes-on maximum drinks consumed in a 24-hour period (maxdrinks) and alcohol use disorder (AUD) symptoms. 25410943 2014
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE Two genes that encode enzymes of alcohol metabolism have the strongest effect on AUD: aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B each has strongly protective variants that reduce risk, with odds ratios approximately 0.2-0.4. 25307596 2014
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE For example, among those without protective alleles for ADH1B or ADH1C, OR for AUD was 1.87 as compared to those without the protective allele for ADH1B only and was 3.16 as compared to those with protective alleles for both ADH1B and ADH1C. 23895337 2013
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE Our previous case-control study in a Tibetan population noted that the positive association between c2 allele of cytochrome P4502E1 (CYP2E1) gene and AUD might only exist in males who are homozygotes for 1 alleles of aldehyde dehydrogenase-2 (ALDH2) and alcohol dehydrogenase-1B (ADH1B) genes, but this interaction did not reach statistical significance. 21402122 2011
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease CTD_human Variation in the ADH1B proximal promoter affects expression. 21168396 2011
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE This study examined additive and interactive effects of ALDH2 and ADH1B genotypes on drinking behavior in a mixed-gender sample of Asian young adults, focusing on continuous phenotypes (e.g., heavy episodic and hazardous drinking, alcohol sensitivity, drinking consequences) whose expression is expected to precede the onset of alcohol use disorders. 19298323 2009
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease CTD_human Acetaldehyde, polymorphisms and the cardiovascular system. 17590986 2007
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE These findings suggest that studies searching for genes relating to the LR to alcohol as a vulnerability factor for AUDs should consider controlling for ADH1B genotype, as the ADH1B*2 allele could obscure the impact of other genetic polymorphisms. 16930209 2006
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease BEFREE These findings are consistent with the hypothesis that enhanced sensitivity to alcohol and lower levels of alcohol use reflect the mechanism by which ADH1B*2 protects against developing an AUD. 16117582 2005
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease CTD_human Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. 16404797 2005
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE However, multivariate analyses under a hierarchically well-formulated model strategy with interaction and confounding assessment indicated that (i) heavy alcohol intake was a significant risk factor (odds ratio per 1.0 g of daily ethanol intake; 1.096, 95% confidence interval; 1.026-1.171) for developing AUD after adjusting for other confounders; and (ii) ADH2*1/1 genotype and ALDH2*1/1 genotype were not risk factors after adjusting for daily ethanol intake and other confounders. 15679538 2005
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease BEFREE The present findings suggest that one of the genetic factors that may be related to probable AUD among Thai males living in the north-east is the ADH2 gene. 12519453 2003
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE Because family history of alcoholism is one of the best predictors of the development of alcohol use disorders, this pilot study suggests that, in this sample of African American young adults, the ADH2*3 allele may be associated with a lowered risk for the development of alcoholism. 11781511 2001
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease BEFREE ADH2*2, however, was not related to alcohol use disorders, alcohol-induced flushing and associated symptoms, number of binge drinking episodes in the past 90 days, maximum number of drinks ever consumed, or self-reported levels of response to alcohol. 11545539 2001
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 GeneticVariation disease BEFREE Among the Atayal, the group with alcohol use disorders (alcohol dependence and alcohol abuse) had a significantly lower frequency of the ADH2*2 allele (0.82) than those without alcohol use disorders (0.91). 7943668 1994