|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The primary outcomes were daily alcohol consumption, binge drinking, problem drinking (CAGE score 2+) and smoking status in relation to tagging variants within the FTO and ADH1B genes.
|
31055022 |
2019 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
BEFREE |
As there was a substantial amount of subjects with alcohol abuse between both groups of patients, ADH1B is unlikely to affect the susceptibility to methanol poisoning.
|
29968299 |
2018 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Certain ADH1B alleles have large effects on alcohol metabolism, and this relationship particularly encourages further investigations in relation to alcoholism and alcohol-associated cancer to understand better the mechanisms by which alcohol metabolism contributes to alcohol abuse and carcinogenesis.
|
28349588 |
2018 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ADH1B*1/*1 genotype tended to be positively associated with problem drinking in the older group (P = 0.080) but not in the younger group.
|
26825972 |
2016 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The high prevalence of the ALDH2*2 and ADH1B*2 alleles in a large percentage of Asian subgroups has been studied as a potential protective factors against alcohol abuse, yet some individuals who possess these genes still engage in problematic alcohol use (Wall et al.2001).
|
27159808 |
2016 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.
|
24018899 |
2014 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence.
|
24553426 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence.
|
24553426 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.
|
24018899 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
BEFREE |
The ADH1B gene has consistently been implicated in problem drinking, but rarely incorporated into gene by environment investigations of alcohol phenotypes.
|
25410943 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The ADH1B gene has consistently been implicated in problem drinking, but rarely incorporated into gene by environment investigations of alcohol phenotypes.
|
25410943 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The ADH1B genotype was associated with the frequency and volume of drinking but its associations with binge drinking and problem drinking were less consistent.
|
22150722 |
2012 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ADH1B genotype was associated with the frequency and volume of drinking but its associations with binge drinking and problem drinking were less consistent.
|
22150722 |
2012 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Variation in the ADH1B proximal promoter affects expression.
|
21168396 |
2011 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Acetaldehyde, polymorphisms and the cardiovascular system.
|
17590986 |
2007 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ADH2*1/*1 and the ADH3*1/*1 genotypes were statistically significantly more common among the patients who abuse alcohol than in the control group.
|
17454860 |
2007 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
|
16404797 |
2005 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Among the Atayal, the group with alcohol use disorders (alcohol dependence and alcohol abuse) had a significantly lower frequency of the ADH2*2 allele (0.82) than those without alcohol use disorders (0.91).
|
7943668 |
1994 |