|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the EA GWAS, three loci were genome-wide significant: rs1229984 in ADH1B for AD criterion count (P = 4.16E-11) and Desire to cut drinking (P = 1.21E-11); rs188227250 (chromosome 8, Drinking more than intended, P = 6.72E-09); rs1912461 (chromosome 15, Time spent drinking, P = 1.77E-08).
|
31090166 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.
|
31591379 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
|
31090166 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the ADH1B and ALDH2 genotypes in Japanese men with alcohol dependence.
|
31845443 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings demonstrate that these variants, which were highly linked with ALDH2 rs671 and ADH1B rs1229984, were significant modulators for AD in our Han Chinese cohort.
|
31591379 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We also examined the extent to which an single nucleotide polymorphism (rs1229984) in ADH1B, which is strongly associated with both alcohol consumption and dependence, contributed to the polygenic association with these phenotypes and whether PRS interacted with sex, age, or family history of alcoholism to predict alcohol-related outcomes.
|
30994927 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Variations in genes affecting alcohol metabolism (ADH1B, ALDH2) are protective against both alcohol dependence and excessive consumption, but different variants are found in different populations.
|
30852706 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Certain ADH1B alleles have large effects on alcohol metabolism, and this relationship particularly encourages further investigations in relation to alcoholism and alcohol-associated cancer to understand better the mechanisms by which alcohol metabolism contributes to alcohol abuse and carcinogenesis.
|
28349588 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We evaluated associations between the presence of fatty liver and ADH1B and ALDH2 genotypes and other factors in 1604 Japanese men who had been admitted for treatment of alcohol dependence.
|
29063269 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism.
|
28610454 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although prior studies reported effects of ADH1B and ALDH2 on lifetime measures, such as risk of alcohol dependence, our study adds further evidence of the effect of the same genes on a cross-sectional measure of average drinking.
|
28485404 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
|
28714907 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The enhanced AER in ADH1B*2 carriers and the increased sAcH levels in ALDH2*1/*2 carriers among intoxicated alcoholics provide possible mechanisms explaining how each genetic polymorphism affects the risk of alcoholism and upper aerodigestive tract cancer.
|
27087413 |
2016 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Functional missense mutations in ADH1B and ALDH2 are protective against alcohol dependence.
|
27338962 |
2016 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed.
|
27172571 |
2016 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genes in alcohol metabolism pathway, especially ADH1B and ALDH2, conferred the major genetic risk for AD in Taiwanese Han population.
|
26842247 |
2016 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We also investigated the relationship of ADH1B variants to the maximum number of drinks consumed in a 24-hour period (MaxDrinks), a presumed intermediate phenotype of AD.
|
25828809 |
2016 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In BP+AD patients, logistic regression analysis showed main effects of ALDH2*1/*1 and ADH1B*1/*1 only in the BP-II+AD group.
|
26033520 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the rare ADH1B rs1229984 mutation provides significant protection against ADS in this British and Irish population; other variants in the ADH gene cluster also alter ADS risk, although the strong linkage disequilibrium between SNPs at this location precluded clear identification of the variant(s) driving the associations.
|
24735490 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ADH1B and ADH1C genetic variations are not related to the development of alcoholism or susceptibility to alcoholic cirrhosis.
|
26042511 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
It has been well documented that variant alleles of both ADH1B*2 of alcohol dehydrogenase (ADH) and ALDH2*2 of aldehyde dehydrogenase (ALDH) protect against the development of alcoholism in East Asians.
|
25365528 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.
|
25410943 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three mQTLs (rs2173201, rs4147542, and rs4147541 in ADH1B-AHD1C gene cluster region) found in AAs were previously identified by our genome-wide association studies as being significantly associated with AD in AAs.
|
24889829 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It has been well documented that variant alleles of both ADH1B*2 of alcohol dehydrogenase (ADH) and ALDH2*2 of aldehyde dehydrogenase (ALDH) protect against the development of alcoholism in East Asians.
|
25365528 |
2014 |