Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism.
|
28610454 |
2018 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis results suggested that a potential relationship between ADH1C <sup>*</sup>1/<sup>*</sup>2 polymorphism and AD risk in Turkish population.
|
29438797 |
2018 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Other ADH and ALDH variants, including functional variations in ADH1C, have also been implicated in affecting drinking behavior and risk for alcoholism.
|
30320893 |
2018 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Certain genetic variants (i.e., alleles)--particularly the ADH1B*2, ADH1B*3, ADH1C*1, and ALDH2*2 alleles--have been associated with lower rates of alcohol dependence.
|
27163368 |
2016 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were also observed between ADS risk and the ADH1B/1C intergenic variant, rs1789891 [allelic P = 7.2 × 10(-5) , OR = 1.4 (1.2, 1.6)] and three non-synonymous SNPs rs698, rs1693482 and rs283413 in ADH1C.
|
24735490 |
2015 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample.
|
25372623 |
2015 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ADH1B and ADH1C genetic variations are not related to the development of alcoholism or susceptibility to alcoholic cirrhosis.
|
26042511 |
2015 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample.
|
25372623 |
2015 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Regular male drinkers without alcohol dependence (n = 112) ages 18-25 years participated in alcohol challenge sessions consisting of placebo and two doses of alcohol (target BrAC: 0 g/dl for placebo, .04 g/dl low dose, and .08 g/dl high dose) and genotyped for variants in ADH1B*3 and ADH1C*2.
|
25208201 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Regular male drinkers without alcohol dependence (n = 112) ages 18-25 years participated in alcohol challenge sessions consisting of placebo and two doses of alcohol (target BrAC: 0 g/dl for placebo, .04 g/dl low dose, and .08 g/dl high dose) and genotyped for variants in ADH1B*3 and ADH1C*2.
|
25208201 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
ADH1B*2, ADH1B*3 and ADH1C*2) that significantly affect the risk of alcohol dependence are rare variants in most populations.
|
23019235 |
2013 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ADH1B*2, ADH1B*3 and ADH1C*2) that significantly affect the risk of alcohol dependence are rare variants in most populations.
|
23019235 |
2013 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Despite a number of potential differences between the samples investigated by the prior GWAS and the current study, data presented here provide additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence and extend this finding by demonstrating association with consumption levels in both non-alcoholic and alcohol-dependent populations.
|
23516558 |
2013 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Despite a number of potential differences between the samples investigated by the prior GWAS and the current study, data presented here provide additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence and extend this finding by demonstrating association with consumption levels in both non-alcoholic and alcohol-dependent populations.
|
23516558 |
2013 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
No associations between alcohol dependence and polymorphisms in ADH1C were found.
|
22931071 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No associations between alcohol dependence and polymorphisms in ADH1C were found.
|
22931071 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Studies with other related polymorphisms are needed to more precisely estimate the association of alcohol dependence with ADH1C.
|
22414625 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings support that ADH1C Ile may lower the risk of AD and alcohol abuse as well as alcohol-related cirrhosis in pooled populations, with the strongest and most consistent effects in Asians.
|
22476623 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected.
|
22325912 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genes ADH1B and ADH1C have certain functional SNPs that are related to alcoholism.
|
21303386 |
2011 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.
|
22048268 |
2011 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We develop a pharmacokinetic model describing how genetic variations in ADH1B, ADH1C, ADH7, ALDH2, and TAS2R38 affect consumption behavior, and alcohol and acetaldehyde levels over time in various tissues of individuals with a particular genotype to predict their susceptibility to alcohol dependence.
|
20714161 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the Polish men examined, ADH1C*1 and ADH1B*1 alleles and ADH1C*1/*1 and ADH1B*1/*1 genotypes favor alcohol dependence.
|
20401433 |
2010 |