|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Polo-like kinase 3 (Plk3) is a serine/threonine protein kinase known to inhibit the cellular response to hypoxia and tumorigenesis.
|
28515325 |
2017 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Here we discuss the role of Plk3 in the hypoxic response and tumorigenesis in light of these latest findings.
|
28857653 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Polo-like kinase 2 (Plk2) and Polo-like kinase 3 (Plk3) have been documented as a tumor suppressor and are lowly expressed in several types of cancer.
|
27423313 |
2016 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Members of the polo-like kinases (Plk1, Plk2, Plk3 and Plk4) are involved in the regulation of various stages of the cell cycle and have been implicated in cancer progression.
|
20473878 |
2011 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We also identified three biological pathways including glycolysis, cell cycle checkpoint II and plk3 pathways in which most genes are systematically up-regulated in many types of cancer.
|
17989776 |
2007 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer.
|
12514133 |
2003 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer.
|
12514133 |
2003 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PLK3 was significantly downregulated in CRC tissues and its low expression was correlated with worse prognosis of patients.
|
31655629 |
2019 |
|
Myopia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conducted a prospective study with patients with myopia or myopic astigmatism undergoing PRK in the same conditions.
|
29340891 |
2019 |
|
Myopic astigmatism
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conducted a prospective study with patients with myopia or myopic astigmatism undergoing PRK in the same conditions.
|
29340891 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study suggests that PLK3 inhibits glucose metabolism by targeting HSP90/STAT3/HK2 signaling and PLK3 may serve as a potential therapeutic target in colorectal cancer.
|
31655629 |
2019 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These serine-threonine kinases compromises MAPK14, RPSK6KA1, RIPK1, and PLK3 and were all previously identified as key-regulators in hepatocarcinogenesis and subject of study for chemotherapeutic interventions.
|
29432895 |
2018 |
|
High astigmatism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
One hundred ninety-six eyes (196 patients) with moderate to high astigmatism (≥ 1.75 D) treated with WFO or CWFG trans-PRK (101 and 95 eyes, respectively) were retrospectively registered.
|
29940974 |
2018 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we identified shared loci between FNK BMD and RA using conjunction cFDR (ccFDR).
|
28854271 |
2017 |
|
Granular Dystrophy, Corneal
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among 24 clinical GCD patients, the proportion of R124H, R555Q, R124L, R555W and R124C were 37.5%, 16.7%, 25.0%, 20.8% and 0%, respectively, and 2 patients had been diagnosed with GCD according to the opacities thriving after LASIK (R124H) and PRK (R555W).
|
28377594 |
2017 |
|
Refractive Errors
|
0.010 |
Biomarker
|
group |
BEFREE |
Cross-linking can halt the disease progression, intrastromal corneal ring segments can improve the corneal shape and hence the visual quality and reduce the refractive error, PRK can correct mild-moderate refractive error, and intraocular lenses can correct from low to high refractive error associated with keratoconus.
|
29403662 |
2017 |
|
Prion Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Polo-like kinase 3 (PLK3) is the main cause of cell cycle reentry-related neuronal apoptosis which has been implicated in the pathogenesis of prion diseases.
|
27344333 |
2017 |
|
Carcinoma of anal margin
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In the present study we aimed to investigate the clinical relevance of Plk3 expression and phosphorylation of caspase-8 at T273 in patients with anal squamous cell carcinoma (SSC) treated with 5-fluorouracil and mitomycin C-based chemoradiotherapy (CRT).
|
27462786 |
2016 |
|
Anal squamous cell carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In the present study we aimed to investigate the clinical relevance of Plk3 expression and phosphorylation of caspase-8 at T273 in patients with anal squamous cell carcinoma (SSC) treated with 5-fluorouracil and mitomycin C-based chemoradiotherapy (CRT).
|
27462786 |
2016 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Patients with high scores of Plk3 and pT273 caspase-8 showed increased local control (p = 0.011; p = 0.001), increased CSS (p = 0.011; p = 0.013) and OS (p = 0.024; p = 0.001), while the levels of pT273 caspase-8 were significantly associated (p = 0.033) with distant metastases.
|
27462786 |
2016 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these data suggest that HOXA-AS2 could be an oncogene for GC partly through suppressing P21, PLK3, and DDIT3 expression; HOXA-AS2 may be served as a candidate prognostic biomarker and target for new therapies in human GC.
|
26384350 |
2015 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Polo-like kinase 3 is associated with improved overall survival in cholangiocarcinoma.
|
25818805 |
2015 |
|
Congenital contractural arachnodactyly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Indeed, rhFGF rapidly increased PLK3 mRNA expression all three CCA cell lines giving an explanation for the abundant PLK3 presence in the tissue samples.
|
25818805 |
2015 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these data suggest that HOXA-AS2 could be an oncogene for GC partly through suppressing P21, PLK3, and DDIT3 expression; HOXA-AS2 may be served as a candidate prognostic biomarker and target for new therapies in human GC.
|
26384350 |
2015 |
|
Retinoblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Retinoblastoma loss led to alteration in DNA damage repair and activation of the NF-κB pathway and subsequent cellular apoptosis through PLK3.
|
25165096 |
2014 |