|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since marijuana intoxication has a potent blocking effect on short-term memory we examined the association between the CNR1 alleles and the P300 wave amplitude at three electrodes in 35 alcohol and drug addicts, by MANOVA.
|
9106243 |
1997 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
The central cannabinoid receptor (CB1) mediates the pharmacological activities of cannabis, the endogenous agonist anandamide and several synthetic agonists.
|
10441206 |
1999 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using Chinese hamster ovary cells stably transfected with the CB(1) receptor cDNA we show here that Delta(9)-tetrahydrocannabinol (THC), the major active component of marijuana, induces the activation of protein kinase B/Akt (PKB).
|
10749665 |
2000 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
The identification of a G-protein-coupled receptor, namely, the cannabinoid receptor (CB1 receptor) that was activated by Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive component of marijuana, led to the discovery of endogenous cannabinoid agonists.
|
12052043 |
2002 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
The CB1/Cnr1 receptor is the major brain site at which cannabinoid marijuana constituents are psychoactive as well as the principal brain receptor for endogenous anandamide ligands.
|
15289816 |
2004 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied four single-nucleotide polymorphisms (SNPs) in the CNR1 gene for association with having one or more symptoms of cannabis dependence in 541 adolescent subjects who had all tried cannabis five or more times.
|
16917946 |
2006 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
To examine whether variants within the cannabinoid receptor (CNR1) and alpha(7) nicotinic receptor (CHRNA7) genes are associated with schizophrenia, and whether these effects vary according to cannabis or tobacco use.
|
17978319 |
2007 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
CTD_human |
Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
|
19016476 |
2009 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings are in accord with earlier reported associations between CNR1 and FAAH and CD intermediate phenotypes, and suggest that the underlying mechanism of these genetic effects may be enhanced neural response in reward areas of the brain in carriers of the CNR1 G allele and FAAH C/C genotype in response to marijuana cues.
|
20010552 |
2010 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of CNR1 tSNPs and marijuana abuse/dependence on brain volumes and neurocognition were assessed using ANCOVA, including co-morbid alcohol/non-marijuana illicit drug misuse as covariates.
|
21420833 |
2011 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the cannabis receptor-1 gene (CNR1), rs2023239, has been associated with CD diagnosis and intermediate phenotypes, including abstinence-induced withdrawal, cue-elicited craving, and parahippocampal activation to cannabis cues.
|
22669173 |
2012 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we assessed the influence of another cannabinoid-related gene, mitogen-activated protein kinase 14 (MAPK14), and potential MAPK14-CNR1 gene-gene interactions in conferring brain volume abnormalities among schizophrenia patients with marijuana abuse/dependence.
|
22850347 |
2013 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CNR1 variation emerged as a moderator of the relationship between trait impulsivity and marijuana problems, thus suggesting that marijuana users with CNR1 risk variants and a higher trait impulsivity are at greater risk for developing marijuana-related problems and supporting a role for CNR1 in a broader impulsivity phenotype.
|
24172113 |
2013 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Then, we studied whether functional variation in CNR1 and cannabis exposure interact in modulating prefrontal function and related behavior during working memory processing.
|
25139064 |
2015 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cannabinoid receptor 1 (CNR1) gene polymorphisms have been associated with central and peripheral effects of cannabis and schizophrenia pathophysiology.
|
26071625 |
2015 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vitro studies suggest that synthetic cannabinoids in these preparations are potent agonists at central cannabinoid CB1 receptors (CB1Rs), but few investigations have delineated their cellular effects, particularly in comparison with the psychoactive component of marijuana, Δ<sup>9</sup> -tetrahydrocannabinol (Δ<sup>9</sup> -THC).
|
26732435 |
2017 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, DLPFC activity in the cluster associated with the CNR1 by PTGS2 interaction was negatively correlated with behavioral efficiency and positively correlated with frequency of cannabis use in cannabis users.
|
27261878 |
2016 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CNR1 haplotypes were formed from four CNR1 SNPs (rs806368, rs1049353, rs2023239, and rs6454674) and tested with level of cannabis exposure to assess their interactive effects on the lingual gyrus, cingulum (right and left) and rolandic operculum, regions showing cannabis exposure effects in the SPM8 analyses.
|
27500453 |
2016 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consumption of cannabinoid receptor-1 (CB-1) agonist such as cannabis is widely taken in 3,4- methylenedioxymethamphetamine (MDMA) or ecstasy users; it has been hypothesized that co-consumption of CB-1 agonist might protect neurons against MDMA toxicity.
|
28167133 |
2017 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Yet, very few studies have been designed to directly assess the role of CB1 receptors in mediating the effects of cannabis on human brain function.
|
28414051 |
2017 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cannabinoid-1 receptor (CB1R) agonist Δ9-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, adversely effects working memory performance in humans.
|
28641496 |
2018 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cannabinoid receptor 1 (CB<sub>1</sub>) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC).
|
28678776 |
2017 |
|
Marijuana Abuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that activation of CB1Rs in VgluT2-expressing glutamate neurons produces aversive effects that might explain why cannabinoid is not rewarding in rodents and might also account for individual differences in the hedonic effects of cannabis in humans.
|
28951549 |
2017 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, delta-9-tetrahydrocannabinol (THC), the primary psychoactive component in cannabis, is associated with acute and neurodevelopmental propsychotic side effects through its interaction with central cannabinoid type 1 receptors (CB1Rs).
|
29063964 |
2018 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that the acute effects of cannabis on anxiety in males are mediated by the modulation of amygdalar function by delta-9-THC and the extent of these effects are related to local availability of CB1 receptors.
|
29101333 |
2017 |