CNR1, cannabinoid receptor 1, 1268

N. diseases: 393; N. variants: 21
Disease: Alcoholic Intoxication, Chronic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 GeneticVariation disease BEFREE In this first human study, we probed CB1R function in individuals vulnerable to alcoholism with the exogenous cannabinoid Δ(9)-tetrahydrocannabinol (Δ(9)-THC). 24424782 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease PSYGENET In this first human study, we probed CB1R function in individuals vulnerable to alcoholism with the exogenous cannabinoid Δ(9)-tetrahydrocannabinol (Δ(9)-THC). 24424782 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease PSYGENET An association between α-syn and CB1 receptors has recently been established in Parkinson's disease, but it is completely unknown whether there is an association between these two proteins in alcohol addiction. 23345080 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease PSYGENET Alcohol dependence is associated with a widespread reduction of cannabinoid CB1 receptor binding in the human brain and this reduction persists at least 2-4 weeks into abstinence. 22776901 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease BEFREE Alcohol dependence is associated with a widespread reduction of cannabinoid CB1 receptor binding in the human brain and this reduction persists at least 2-4 weeks into abstinence. 22776901 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease PSYGENET Cannabinoid receptor 1 gene is associated with alcohol dependence. 22085192 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease BEFREE Cannabinoid receptor 1 gene is associated with alcohol dependence. 22085192 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease BEFREE To achieve a better understanding of the role of the CNR1 gene in the etiology and treatment of alcohol dependence. 18606956 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease PSYGENET To achieve a better understanding of the role of the CNR1 gene in the etiology and treatment of alcohol dependence. 18606956 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 GeneticVariation disease BEFREE CNR1 variation modulates risk for drug and alcohol dependence. 17509535 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 GeneticVariation disease BEFREE Alcoholism-related phenotypes and genetic variants of the CB1 receptor. 14714115 2003
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.370 Biomarker disease BEFREE Similarly, activation of the CB1 receptor system promoted alcohol craving, suggesting a role for the CB1 receptor gene in excessive EtOH drinking behavior and development of alcoholism. 12052043 2002