CNR1, cannabinoid receptor 1, 1268

N. diseases: 393; N. variants: 21
Disease: Drug abuse ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 Biomarker group BEFREE The CB1 receptor antagonist rimonabant has been previously found to prevent behavioral effects of drugs of abuse in a context-dependent manner, suggesting an important role of endocannabinoid signaling in drug-induced environmental conditioning. 28837947 2017
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 GeneticVariation group BEFREE To examine whether a synonymous polymorphism, rs1049353, in exon 4 of the gene encoding the human endocannabinoid receptor (CNR1) moderates the effect of self-reported childhood physical abuse on lifetime anhedonia and depression and to replicate this interaction in an independent sample. 22393204 2012
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 Biomarker group CTD_human Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. 21513772 2011
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 Biomarker group CTD_human Cannabinoid signaling via the type 1 cannabinoid (CB1) receptor modulates the effects of drugs of abuse and the response to exposure to stressors. 18690112 2008
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 Biomarker group CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857 1999