CNR1, cannabinoid receptor 1, 1268

N. diseases: 393; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.360 Biomarker disease BEFREE These results provide firsthand evidence in support of the protective role of SSTRs in STHdh cells and the possible crosstalk between SSTRs and CB1R in the modulation of excitotoxicity in Huntington's disease. 31381945 2019
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.360 Biomarker disease BEFREE These findings support the idea that CNR1 variation may have modifying effects on the AO in HD. 23747361 2013
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.360 Biomarker disease BEFREE Here we determined whether CB(1) downregulation measured in patients with HD and mouse models was ubiquitous or restricted to specific striatal neuronal subpopulations. 23167744 2013
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.360 AlteredExpression disease BEFREE Furthermore, CNR1 receptor is downregulated in Huntington's disease and upregulated in Parkinson's disease. 21266946 2012
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.360 Biomarker disease BEFREE As a result, the balance between CB1Rs expressed by the two neuronal populations and, thus, the net effect of CB1R stimulation, is profoundly altered in HD mice. 22207189 2012
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.360 Biomarker disease CTD_human Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. 20929960 2011
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.360 AlteredExpression disease BEFREE However, in Huntington's disease there is a very early downregulation of CB(1) receptors in striatal neurons that, together with the undesirable psychoactive effects triggered by CB(1) receptor activation, foster the search for alternative pharmacological treatments. 19805493 2009