CNTF, ciliary neurotrophic factor, 1270

N. diseases: 114; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease. 9342199 1997
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE It is concluded that the CNTF null mutation may be relevant to the aetiopathogenesis of schizophrenia in some patients, but further work is required to identify specifically the patient group for which it is important. 8856688 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Our results suggest that the polymorphisms at the DRD3, 5HTR2A, CNTF and BDNF gene loci are unlikely to make our sample more genetically susceptible to schizophrenia. 11343865 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE We investigated the association between a null mutation in the ciliary neurotrophic factor (CNTF) gene and functional psychoses including schizophrenia and schizoaffective disorder. 9601653 1998
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Ciliary neurotrophic factor null mutation and schizophrenia in a Swedish population. 9285965 1997
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease LHGDN Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial. 18303965 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial. 18303965 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Our results did not provide evidence for the involvement of the null mutation of the CNTF gene in the development of schizophrenia. 9247976 1997
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE These results suggested that the variations at the NT3 and the CNTF genes do not influence the schizophrenia risk, but a role in the susceptibility of subgroups of the patients cannot be excluded. 15474906 2004
CUI: C4551993
Disease: Amyotrophic Lateral Sclerosis, Familial
Amyotrophic Lateral Sclerosis, Familial 		0.320 GeneticVariation disease BEFREE Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. 11951178 2002
CUI: C4551993
Disease: Amyotrophic Lateral Sclerosis, Familial
Amyotrophic Lateral Sclerosis, Familial 		0.320 GeneticVariation disease BEFREE Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis. 8543936 1995
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.310 GeneticVariation disease BEFREE In addition, patients with sporadic amyotrophic lateral sclerosis who had a homozygous CNTF gene defect showed significantly earlier disease onset but did not show a significant difference in disease duration. 11951178 2002
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 GeneticVariation disease BEFREE We failed to detect an earlier onset of HD in nine homozygotes and 71 heterozygotes with this CNTF mutation compared with 203 homozygotes with wild-type alleles. 9305364 1997
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation disease BEFREE Ciliary neurotrophic factor null alleles are not a risk factor for Charcot-Marie-Tooth disease, hereditary neuropathy with pressure palsies and amyotrophic lateral sclerosis. 17651970 2007
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation disease LHGDN Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. 11951178 2002
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
Low density lipoprotein cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0428474
Disease: Serum LDL cholesterol measurement
Serum LDL cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 GeneticVariation disease BEFREE Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease. 9342199 1997
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 GeneticVariation disease LHGDN Similar genotype frequencies for the CNTF mutation were obtained in MS patients (genotype 0101=74.8%, 0102=22.3%, 0202=2.9%) and controls (genotype 0101=71.7%, 0102=26.5%, 0202=1.8%) even after stratification for the HLA-DRB1*15 allele. 11857064 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 GeneticVariation disease BEFREE Similar genotype frequencies for the CNTF mutation were obtained in MS patients (genotype 0101=74.8%, 0102=22.3%, 0202=2.9%) and controls (genotype 0101=71.7%, 0102=26.5%, 0202=1.8%) even after stratification for the HLA-DRB1*15 allele. 11857064 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 GeneticVariation disease BEFREE We screened 288 unselected patients with multiple sclerosis (MS) (mean age, 40.2 +/- 10.2 years; range, 18-71 years) for a previously described homozygous null mutation within the CNTF gene leading to a truncated, biologically inactive protein. 11890844 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 GeneticVariation disease LHGDN We screened 288 unselected patients with multiple sclerosis (MS) (mean age, 40.2 +/- 10.2 years; range, 18-71 years) for a previously described homozygous null mutation within the CNTF gene leading to a truncated, biologically inactive protein. 11890844 2002
CUI: C0028754
Disease: Obesity
Obesity 		0.040 GeneticVariation disease BEFREE In conclusion, variants in the CNTF gene are unlikely to be associated with the development of early-onset obesity. 9628240 1998
CUI: C0035334
Disease: Retinitis Pigmentosa
Retinitis Pigmentosa 		0.040 GeneticVariation disease BEFREE The present study aimed to test whether adeno-associated virus (AAV)-mediated delivery of the gene encoding CNTF delays photoreceptor death in the rhodopsin knockout (opsin(-/-)) mouse, an animal model of RP. 11237681 2001