|
Degenerative polyarthritis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Treatment of OA synoviocytes with forskolin (10 μM) increased intracellular cAMP levels and reduced TGF-β1-stimulated COL1A1, α-SMA, and TIMP-1 expression, with no change in PLOD2 expression.
|
29898378 |
2018 |
|
Degenerative polyarthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 gene might be linked to the susceptibility of musculoskeletal degenerative diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD).
|
29088884 |
2017 |
|
Degenerative polyarthritis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Th present study demonstrated that the expression levels of miR‑210 and COL1A1 were lower, and the expression levels of COL10A1 and MMP13 were higher in the OA chondrocytes, compared with the levels of expression in the normal chondrocytes.
|
26861791 |
2016 |
|
Degenerative polyarthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In OA synovium elevation of collagens and cross-linking enzymes (COL1A1, COL5A1, PLOD2, LOX and TIMP1) responsive to TGF-β was found as well as differential expression pattern between different areas of the osteoarthritic synovial membrane.
|
25456297 |
2014 |
|
Degenerative polyarthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Semi-quantitative reverse transcription-polymerase chain reaction analysis revealed elevated mRNA expression levels of alkaline phosphatase (p < 0.002), osteocalcin (OCN) (p < 0.0001), osteopontin (p < 0.05), COL1A1 (p < 0.0001), and COL1A2 (p < 0.002) in OA bone compared to control, suggesting possible increases in osteoblastic biosynthetic activity and/or bone turnover at the IT region in OA.
|
17187661 |
2006 |
|
Degenerative polyarthritis
|
0.200 |
Biomarker
|
disease |
LHGDN |
CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients.
|
15965952 |
2006 |
|
Degenerative polyarthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results obtained until now can be divided into three sections: (1) genetic analysis of bone mass/size/geometry characteristics (OP) and traits related to hand OA; (2) pedigree-based investigation of circulating levels of calciotropic hormones, growth factors, cytokines, and biochemical indices of bone and cartilage remodelling; (3) linkage and linkage disequilibrium study of several candidate genes, such as estrogen receptor alpha, collagen type I alpha 1, genes related to extracellular inorganic pyrophosphate transport and OP/OA phenotypes, including biochemical variables.
|
15621207 |
2005 |
|
Degenerative polyarthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to examine whether there is an association between COL1A1 Sp1 polymorphism and radiographic osteoarthritis (OA) of the hip in elderly women in the Study of Osteoporotic Fractures.
|
15880349 |
2005 |
|
Degenerative polyarthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
If the VDR, ER, or COL1A1 genes do encode predisposition to OA then the 4 SNP tested are not associated with major susceptibility alleles at these 3 loci.
|
10743824 |
2000 |
|
Degenerative polyarthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To evaluate whether DNA polymorphisms of the VDR (vitamin D receptor), COL1A1 (alpha1 type I collagen), and COL2A1 (alpha1 type II collagen) genes, which have previously been linked to bone mineral density (BMD) and/or osteoarthritis (OA), are also associated with OA of the hip (OAH).
|
9811048 |
1998 |
|
Degenerative polyarthritis
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|