Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats.
|
30938133 |
2019 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-1β stimulus determined a significant regulation of survival, apoptotic ratio, as well as of gene expression and serum levels of MMP-1,-3,-13 and Col2a1 in OA chondrocytes compared to baseline.
|
30316071 |
2018 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.
|
16877351 |
2006 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Spondyloepiphyseal dysplasia and precocious osteoarthritis in a family with an Arg75-->Cys mutation in the procollagen type II gene (COL2A1).
|
8244341 |
1993 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The expressions of FAS-AS1, MMP1, and MMP13 in osteoarthritis tissues increased significantly, while COL2A1 presented a low expression.
|
29863238 |
2018 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Moreover, in the presence of herbal-Leucine mixture (HLM) up-regulation of ACAN and COL2A1 expression in IL-1β-stimulated OA chondrocytes was also noted (p < 0.05).
|
21854562 |
2011 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that CH inhibited cell apoptosis, dose‑dependently reduced matrix metalloproteinase (MMP) 13, collagenase and IL‑6 expression, and increased collagen α‑1 (II) chain (COL2A1) expression in human osteoarthritis chondrocytes.
|
30535473 |
2019 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
MSC-Exos increased chondrogenic genes Col2a1 (type II collagen alpha 1) and aggrecan, decreased hondrocyte hypertrophy markers MMP-13 (matrix metalloproteinase-13) and Runx2 (runt-related transcription factor 2) in chondrocytes isolated from OA model mice.
|
30324848 |
2018 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response.
|
18799084 |
2009 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our study reveals novel mechanisms for the inhibition of chondrocyte hypertrophy by COL2A1 and suggests that the degradation and decrease in COL2A1 might initiate and promote osteoarthritis progression.
|
30854241 |
2019 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In contrast, COL2A1, other collagen genes, and factors associated with skeletal development were up-regulated in late OA, compared with early OA or normal cartilage.
|
18576389 |
2008 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results indicate that genetic polymorphisms affecting knee OA vary between populations (Japanese versus Caucasian) and sexes and indicate a role for ASPN, COMP, FRZB, and COL2A1 in Caucasians.
|
17195216 |
2007 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our results highlight the contribution of ELF3 to transcriptional regulation of COL2A1 and its potential role in OA disease, and uncover epigenetic mechanisms at play in the regulation of ELF3 and its downstream targets in articular chondrocytes.
|
27310669 |
2017 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Following transfection with ds-miRNA-4784, Col2a1 mRNA expression levels increased by 63 and 126% compared with the levels prior to treatment in groups OA at week 4 and 8, respectively (P<0.01).
|
30542421 |
2018 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, miR‑9 inhibits the expression level of MMP‑13, decreases its inhibitory effects on COL2A1, and therefore contributes to antagonizing OA.
|
29286096 |
2018 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis.
|
10735581 |
1999 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Specifically, increased miR-145 levels cause greatly reduced expression of critical cartilage extracellular matrix genes (COL2A1 and aggrecan) and tissue-specific microRNAs (miR-675 and miR-140) and increased levels of the hypertrophic markers RUNX2 and MMP13, characteristic of changes occurring in osteoarthritis.
|
22102413 |
2012 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We review the increasing evidence implicating COL2A1 mutations in individuals presenting with isolated degenerative joint disease, aiming to alert physicians who assess these patients to this possibility.
|
20131279 |
2010 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Long-term Prg4 expression under the type II collagen promoter (Col2a1) does not adversely affect skeletal development but protects from developing signs of age-related OA.
|
23486780 |
2013 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
A type II collagen mutation also results in oto-spondylo-megaepiphyseal dysplasia.
|
16189708 |
2005 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Using the procedure developed for analysis of the COL2A1 gene, mutations were detected in > 20% of patients with chondrodysplasias and up to 2% of patients with early-onset familial OA.
|
7612049 |
1995 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multiallelic polymorphism of the cartilage collagen gene: no association with osteoarthrosis.
|
8257213 |
1993 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We report a patient with severe polyarticular OA starting in young adulthood due to a heterozygous mutation in the COL2A1 gene.
|
22717203 |
2013 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Familial OA with classic clinical and radiographic findings is tightly linked to the COL2A1 gene.
|
8452585 |
1993 |