|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The allele-positivity rate of DRB1*04: 05 was also higher in the ICI-induced inflammatory arthritis group.
|
30508191 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1∗04 molecules modulate the DQ8-restricted response and determine the outcome of arthritis in mice carrying DR4/DQ8 haplotype.
|
25541434 |
2015 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antigen presentation by B cells leads to a sex-specific immune response in DRB1*0401 mice suggesting a role of B cells and HLA-DR in rendering susceptibility to develop arthritis in females.
|
21665435 |
2011 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA class II allele DRB1*0401 is associated with predisposition to Rheumatoid Arthritis in humans as well as collagen-induced arthritis in mice.
|
20061120 |
2010 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In double-Tg mice, the DRB1*0401 gene contributes to the development of collagen-induced arthritis, whereas DRB1*0402 prevents the disease.
|
18684978 |
2008 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, when stratified by antibiotic response, the frequencies of DRB1 alleles in the 71 patients with antibiotic-refractory arthritis differed significantly from those in the 50 antibiotic-responsive patients (log likelihood test, P = 0.006; exact test, P = 0.008; effect size, Wn = 0.38).
|
16585267 |
2006 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The magnitude of OspA(163-175) binding correlated well with the frequencies of the DRB1 alleles in patients with treatment-resistant arthritis, but the binding of hLFA-1alpha(L330-342) showed only an association with the DRB*04 alleles.
|
12571864 |
2003 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo depletion of DRB1*0402 did not lead to induction of collagen-induced arthritis in transgenic mice.
|
14530370 |
2003 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, persistent disease was predicted by the presence of DRB1*08, and joint erosions were predicted by symmetric arthritis and DRB1*08 and HLA-B27 in combination.
|
12563700 |
2003 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1 alleles encoding a DERAA motif in their third hypervariable region provided a strong dominant protection against RA among DQ5-positive individuals and decreased arthritis activity among DQ3-positive patients.
|
11257148 |
2001 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using peptide from DRB1*0402 molecule, known to be associated with resistance to RA, prior to induction of collagen induced arthritis prevents the onset of disease.
|
11163096 |
2000 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Co-immunization of the DRB 1*0402 peptide significantly reduced the severity of arthritis (mean score = 1.5+/-0.6 vs 5.2+/-1.4 in controls), whereas multiple doses of the peptide reduced the incidence of disease (3.5% vs 35-60% in controls).
|
10426274 |
1999 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Complementation between HLA-DR4 (DRB1*0401) and specific H2-A molecule in transgenic mice leads to collagen-induced arthritis.
|
10527388 |
1999 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other HLA-clinical associations included DR2 with pleuritis, DR4 with hand swelling, and DRB1*0405 with arthritis.
|
8651987 |
1996 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When we try to find a common sequence for all DRB1 alleles involved in juvenile and adult arthritis, we can notice hydrophobic amino acid at position 74, which is present in all these alleles, but not in nonsusceptible alleles, where is the hydrophilic amino acid at position 74.
|
8744729 |
1995 |