|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*04*13*14 and DRB1*08 may contribute to the clinical heterogeneity of UC between Han and Uyghur UC patients.
|
23674880 |
2013 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype-based analysis in the major histocompatibility complex region showed that HLA-Cw*1202-B*5201-DRB1*1502 haplotype was significantly associated with increased risk of UC compared with CD (P = 1.1 × 10⁻³³; OR = 6.58), accounting for most of the associations observed in the GWAS.
|
21699788 |
2011 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of DRB1*07 allele was increased in UC patients compared with healthy controls (19.4% vs. 9.2%, P = 0.0229, OR = 2.372, 95%CI: 1.181-4.766), but the significance disappeared when given Bonferroni correction (P(C) = 0.2977).
|
16426241 |
2006 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The allelic combination DRB1*0103/D6S273-5/BAT_2-8/TNFa11b4c1d3e3/IKBL+738(C)/MICA5.1 that includes the telomeric class III markers of the 7.1 ancestral haplotype is highly increased in patients with UC (P=0.0001, OR=10.57), especially in those with the extensive form of the disease (P=0.02, OR=3.41 extensive versus distal).
|
16116311 |
2005 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*1502, which was previously shown to be dominant in Japanese patients with UC, was not observed in this case.
|
16437733 |
2005 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-B*52 and DRB1*1502 are reported to be strongly associated with UC in Japan.
|
15215890 |
2004 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously, we have reported that the DRB1*1502 and DRw11 genes were closely related to the intractability of UC.
|
11993515 |
2002 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data are consistent with those of Japanese studies in that DR2 and DRB1*1502 are positively associated with UC patients.
|
12073071 |
2002 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previously reported association of DR2 with UC was attributable to DRB1*1502 (OR = 2.6, p = 0.006).
|
10689124 |
2000 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DR2, DR9, and DRB1*0103 were positively associated with ulcerative colitis, and a negative association was found for DR4 and ulcerative colitis.
|
10446108 |
1999 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study provides additional evidence for the role of DRB1 alleles in the susceptibility to UC, and supports the hypothesis that these alleles may determine the severity of the disease.
|
9933456 |
1999 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results were as follows: 1) the presence of DQB1*0402 (RR=3.90, Pc=0.0001) was positively associated with CD; 2) the presence of DRB1*1502 (RR=4.51, P<1X10(-8)), DRB5*0102 (RR=4.70, Pc<1x10(-8)), DQA1*0103 (RR=3.72, Pc=1x10(-5)), DQB1*06011 (RR=3.78, PC=1x10(-5)), DPA1*0201 (RR=3.23, Pc=0.0001) and DPB1*0901 (RR=4.83, PC<1x10(8)) was positively associated and that of DRB4*0101 (RR=0.20, Pc<1X10(-8)) and DQA1*0302 (RR=0.34, Pc=0.001) negatively associated with UC; 3) haplotype analysis showed a positive association between the presence of DRB1*0410-DQA1*0302-DQB1*0402 and DRB1*0802-DQA1*0401-DQB1*0402 with CD, and a negative association between the presence of DRB1*1502-DQA1*0103-DQB1*06011 and CD, there was no association of DRB1*08032-DQA1*0103-DQB1*06011 with CD; and 4) in UC, a positive association with the presence of DRB1*1502-DQA1*0103-DQB1*06011 was found, but DRB1*08032-DQA1*0103-DQB1*06011 was not associated with it.
|
10323339 |
1999 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results extended the reported positive association of DRB1*1502 with UC to another population and supported the genetic susceptibility associated with HLA genes for disease development.
|
9777329 |
1998 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the DRB1*13 allele was decreased in patients with UC (15% versus 28% in controls; P = 0.04; OR = 0.5).
|
9218841 |
1997 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the association study the rare DRB1*103 (8.3% vs 3.2% in controls) and DRB1*12 (8.6% vs 2.1% in controls) alleles were associated with ulcerative colitis (p = 0.0074, chi2 = 7.22, odds ratio OR = 2.9 [95% CI 1.3-6.4] and p = 0.0056, chi2 = 12.63, OR = 4.33 [1.8-11.0] respectively).
|
8622450 |
1996 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1*1501 and DRB1*1502 differ in only one amino acid at residue 86 (valine vs glycine), and 66% of the UC patients carried two glycines at position 86 in the HLA-DR beta-chain (vs 51% of control; P < 0.05).
|
7720475 |
1995 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*1502 or DRw11 have a probability of being closely related to the intractability of UC.
|
7942717 |
1994 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significant increase was observed in Bw52, DPw9 (DPB1*0901), and DR2 (DRB1*1502) in Japanese patients with UC.
|
8096500 |
1993 |